Antifungal Activities of Human Beta-Defensins HBD-1 to HBD-3 and Their C-Terminal Analogs Phd1 to Phd3

被引：80

作者：

Krishnakumari, Viswanatha ^{[1
]}

Rangaraj, Nandini ^{[1
]}

Nagaraj, Ramakrishnan ^{[1
]}

机构：

[1] CSIR, Ctr Cellular & Mol Biol, Hyderabad 500007, Andhra Pradesh, India

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 01期

关键词：

ANTIMICROBIAL PEPTIDES; ANTIBACTERIAL ACTIVITIES; HUMAN BETA-DEFENSIN-3; SALIVARY-GLANDS; MAMMALIAN DEFENSINS; DISULFIDE; EXPRESSION; CANDIDA; CONFORMATIONS; BRIDGES;

D O I：

10.1128/AAC.00470-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The activities of defensins HBD-1, HBD-2, and HBD-3 and their C-terminal analogs Phd1, Phd2, and Phd3 against Candida albicans were investigated. Phd1 to Phd3 showed lower-level activities than HBD- 1 to HBD-3, although metabolic inhibitors did not render Phd1 to Phd3 inactive. Their activities were also less salt sensitive than those of HBD- 1 to HBD-3. Confocal microscope images indicated that the initial site of action was the fungal membrane.

引用

页码：256 / 260

页数：5

共 50 条

[1] Expression of human β-defensins HBD-1, HBD-2, and HBD-3, in cultured keratinocytes and skin substitutes
Supp, DM
Karpinski, AC
Boyce, ST
BURNS, 2004, 30 (07) : 643 - 648
[2] Characterisation of NLS in human PHD1 and PHD3
Hilz, A.
Schillinger, T.
Schindler, S. G.
Koehler, M.
Depping, R.
FEBS JOURNAL, 2007, 274 : 108 - 108
[3] Candida albicans induces tissue-specific human beta-defensins (HBD)-1, HBD-2 and HBD-3 secretion in human amniochorionic membranes
Zaga-Clavellina, V.
Ruiz Velasco-Munoz, M.
Flores-Espinosa, P.
Vega-Sanchez, R.
Estrada-Gutierrez, G.
Flores-Pliego, A.
Espejel-Nunez, A.
Sosa-Gonzalez, I.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2012, 94 (01) : 37 - 37
[4] Inhibition of hBD-3, but not hBD-1 and hBD-2, mRNA expression by corticosteroids
Duits, LA
Rademaker, M
Ravensbergen, B
van Sterkenburg, MAJA
van Strijen, E
Hiemstra, PS
Nibbering, PH
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 280 (02) : 522 - 525
[5] Use of human reconstructed epidermis to analyze the regulation of β-defensin hBD-1, hBD-2, and hBD-3 expression in response to LPS
P. Chadebech
D. Goidin
C. Jacquet
J. Viac
D. Schmitt
M-J. Staquet
Cell Biology and Toxicology, 2003, 19 : 313 - 324
[6] Use of human reconstructed epidermis to analyze the regulation of β-defensin hBD-1, hBD-2, and hBD-3 expression in response to LPS
Chadebech, P
Goidin, D
Jacquet, C
Viac, J
Schmitt, D
Staquet, MJ
CELL BIOLOGY AND TOXICOLOGY, 2003, 19 (05) : 313 - 324
[7] PHD1 and PHD3 are expressed in bone cells but are not essential for bone homeostasis
Laperre, K.
Smets, N.
Bouillon, R.
Carmeliet, P.
Carmeliet, G.
JOURNAL OF BONE AND MINERAL RESEARCH, 2007, 22 : S263 - S263
[8] Tissue-specific human beta-defensins (HBD)-1, HBD-2 and HBD-3 secretion profile from human amniochorionic membranes stimulated with Candida albicans in a two-compartment tissue culture system
Zaga-Clavellina, Veronica
Ruiz, Martha
Flores-Espinosa, Pilar
Vega-Sanchez, Rodrigo
Flores-Pliego, Arturo
Estrada-Gutierrez, Guadalupe
Sosa-Gonzalez, Irma
Morales-Mendez, Iyari
Osorio-Caballero, Mauricio
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 2012, 10
[9] A Molecular Dynamics Study of Human Defensins HBD-1 and HNP-3 in Water
Sharadadevi, Ambure
Nagaraj, Ramakrishnan
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2010, 27 (04): : 541 - 550
[10] Tissue-specific human beta-defensins (HBD)-1, HBD-2 and HBD-3 secretion profile from human amniochorionic membranes stimulated with Candida albicans in a two-compartment tissue culture system
Veronica Zaga-Clavellina
Martha Ruiz
Pilar Flores-Espinosa
Rodrigo Vega-Sanchez
Arturo Flores-Pliego
Guadalupe Estrada-Gutierrez
Irma Sosa-Gonzalez
Iyari Morales-Méndez
Mauricio Osorio-Caballero
Reproductive Biology and Endocrinology, 10

← 1 2 3 4 5 →