Inhibitory effect of the tea polyphenol, (-)-epigallocatechin gallate, on growth of cervical adenocarcinoma cell lines

被引：42
|
作者：
Noguchi, M [1 ]
Yokoyama, M [1 ]
Watanabe, S [1 ]
Uchiyama, M [1 ]
Nakao, Y [1 ]
Hara, K [1 ]
Iwasaka, T [1 ]
机构：
[1] Saga Univ, Fac Med, Dept Obstet & Gynecol, Saga 8498501, Japan
来源：
CANCER LETTERS | 2006年 / 234卷 / 02期
关键词：
cervical adenocarcinoma; EGCG; telomerase; apoptosis; pKi-67;
D O I：
10.1016/j.canlet.2005.03.053
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
To investigate the effect of (-)-epigallocatechin gallate (EGCG) on cervical adenocarcinoma, we performed a cell proliferation assay. TRAP assay is used for telomerase activity, How cytometry analysis and pKi-67 immunofluoroscein staining in cervical adenocarcinoma cell lines (OMC-4, TMCC-1). Our results showed that EGCG inhibited the proliferation assay, TRAP assay for telomerase activity of both cell lines. Although cell apoptosis was induced, we observed that the expression of pKi-67 was Suppressed. Our data suggest that EGCG may be effective for the treatment of cervical adenocarcinoma. The mechanisms of the anti-tumor effects were revealed to be the inhibition of telomerase activity, the induction of apoptosis and cell cycle dysregulation. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：135 / 142
页数：8
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