Inhibitory effect of the tea polyphenol, (-)-epigallocatechin gallate, on growth of cervical adenocarcinoma cell lines

被引：42

作者：

Noguchi, M ^{[1
]}

Yokoyama, M ^{[1
]}

Watanabe, S ^{[1
]}

Uchiyama, M ^{[1
]}

Nakao, Y ^{[1
]}

Hara, K ^{[1
]}

Iwasaka, T ^{[1
]}

机构：

[1] Saga Univ, Fac Med, Dept Obstet & Gynecol, Saga 8498501, Japan

来源：

CANCER LETTERS | 2006年 / 234卷 / 02期

关键词：

cervical adenocarcinoma; EGCG; telomerase; apoptosis; pKi-67;

D O I：

10.1016/j.canlet.2005.03.053

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To investigate the effect of (-)-epigallocatechin gallate (EGCG) on cervical adenocarcinoma, we performed a cell proliferation assay. TRAP assay is used for telomerase activity, How cytometry analysis and pKi-67 immunofluoroscein staining in cervical adenocarcinoma cell lines (OMC-4, TMCC-1). Our results showed that EGCG inhibited the proliferation assay, TRAP assay for telomerase activity of both cell lines. Although cell apoptosis was induced, we observed that the expression of pKi-67 was Suppressed. Our data suggest that EGCG may be effective for the treatment of cervical adenocarcinoma. The mechanisms of the anti-tumor effects were revealed to be the inhibition of telomerase activity, the induction of apoptosis and cell cycle dysregulation. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：135 / 142

页数：8

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