Ultrastructural Effects of Oritavancin on Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococcus

被引：31
|
作者：
Belley, Adam [1 ]
Harris, Robert [2 ]
Beveridge, Terry [2 ]
Parr, Tom, Jr. [1 ]
Moeck, Gregory [1 ]
机构：
[1] Targanta Therapeut Inc, St Laurent, PQ H4S 2A1, Canada
[2] MicroTEM Inc, Elora, ON N0B 1S0, Canada
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 02期
关键词：
CELL-WALL; GLYCOPEPTIDE ANTIBIOTICS; DIVISION; MICROSCOPY; SEPARATION; MECHANISM; FORCE;
D O I：
10.1128/AAC.00603-08
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The ultrastructural effects of the lipoglycopeptide oritavancin on methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococcus (VRE) were examined by transmission electron microscopy. Oritavancin but not vancomycin induced aberrant septum formation and loss of staining of nascent septal cross walls in MRSA. Septal distortions were also observed in VRE exposed to oritavancin.
引用
收藏
页码：800 / 804
页数：5
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