Ultrastructural Effects of Oritavancin on Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococcus

被引：31
|
作者：
Belley, Adam [1 ]
Harris, Robert [2 ]
Beveridge, Terry [2 ]
Parr, Tom, Jr. [1 ]
Moeck, Gregory [1 ]
机构：
[1] Targanta Therapeut Inc, St Laurent, PQ H4S 2A1, Canada
[2] MicroTEM Inc, Elora, ON N0B 1S0, Canada
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 02期
关键词：
CELL-WALL; GLYCOPEPTIDE ANTIBIOTICS; DIVISION; MICROSCOPY; SEPARATION; MECHANISM; FORCE;
D O I：
10.1128/AAC.00603-08
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The ultrastructural effects of the lipoglycopeptide oritavancin on methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococcus (VRE) were examined by transmission electron microscopy. Oritavancin but not vancomycin induced aberrant septum formation and loss of staining of nascent septal cross walls in MRSA. Septal distortions were also observed in VRE exposed to oritavancin.
引用
收藏
页码：800 / 804
页数：5
相关论文
共 50 条
  • [31] Linezolid for methicillin-resistant Staphylococcus aureus or vancomycin-resistant Enterococcus infection: meta-analysis of randomized trials
    Martin, J.
    Sawh, S.
    Newman, J.
    Deshpande, S.
    [J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2009, 34 : S24 - S24
  • [32] Environmental Panels as a Proxy for Nursing Facility Patients With Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococcus Colonization
    Cassone, Marco
    Mantey, Julia
    Perri, Mary Beth
    Gibson, Kristen
    Lansing, Bonnie
    McNamara, Sara
    Patel, Payal K.
    Cheng, Vincent C. C.
    Walters, Maroya S.
    Stone, Nimalie D.
    Zervos, Marcus J.
    Mody, Lona
    [J]. CLINICAL INFECTIOUS DISEASES, 2018, 67 (06) : 861 - 868
  • [33] Natural history of colonization with methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE): a systematic review
    Shenoy, Erica S.
    Paras, Molly L.
    Noubary, Farzad
    Walensky, Rochelle P.
    Hooper, David C.
    [J]. BMC INFECTIOUS DISEASES, 2014, 14
  • [34] Methicillin-resistant Staphylococcus aureus, Vancomycin-resistant Enterococcus faecalis and Enterococcus faecium active Dimeric Isobutyrylphloroglucinol from Ivesia gordonii
    Ahmed, Marwa H.
    Ibrahim, Mohamed Ali
    Zhang, Jin
    Melek, Farouk R.
    El-Hawary, Seham S.
    Jacob, Melissa R.
    Muhammad, Ilias
    [J]. NATURAL PRODUCT COMMUNICATIONS, 2014, 9 (02) : 221 - 224
  • [35] Effects of daily bathing with chlorhexidine and acquired infection of methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus: a meta-analysis
    Chen, Wensen
    Li, Songqin
    Li, Lianhong
    Wu, Xin
    Zhang, Weihong
    [J]. JOURNAL OF THORACIC DISEASE, 2013, 5 (04) : 518 - 524
  • [36] Prevalence of Colonization and Infection with Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococcus and of Clostridium difficile Infection in Canadian Hospitals
    Simor, Andrew E.
    Williams, Victoria
    McGeer, Allison
    Raboud, Janet
    Larios, Oscar
    Weiss, Karl
    Hirji, Zahir
    Laing, Felicia
    Moore, Christine
    Gravel, Denise
    [J]. INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2013, 34 (07): : 687 - 693
  • [37] Impact of Discontinuing Contact Precautions for Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococcus: An Interrupted Time Series Analysis
    Bearman, Gonzalo
    Abbas, Salma
    Masroor, Nadia
    Sanogo, Kakotan
    Vanhoozer, Ginger
    Cooper, Kaila
    Doll, Michelle
    Stevens, Michael P.
    Edmond, Michael B.
    [J]. INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2018, 39 (06): : 676 - 682
  • [38] The Importance of Contact Precautions for Endemic Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci
    Rubin, Michael A.
    Samore, Matthew H.
    Harris, Anthony D.
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2018, 319 (09): : 863 - 864
  • [39] Nosocomial infections due to methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus:: Relationships with antibiotic use and cost drivers
    Mauldin, Patrick D.
    Salgado, Cassandra D.
    Durkalski, Valerie L.
    Bosso, John A.
    [J]. ANNALS OF PHARMACOTHERAPY, 2008, 42 (03) : 317 - 326
  • [40] A Hidden Reservoir of Methicillin-resistant Staphylococcus aureus and Vancomycin-resistant Enterococcus in Patients Newly Admitted to an Acute Rehabilitation Hospital
    Rabinowitz, Ronald P.
    Kufera, Joseph A.
    Makley, Michael J.
    [J]. PM&R, 2012, 4 (01) : 18 - 22
12345