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Synthesis of Some 5-[2-Aryl-2-oxoethyl]-1,3-dimethylpyrimidine-2,4,6-trione Derivatives by a One-pot, Three-component Reaction
被引:4
|作者:
Khalafy, Jabbar
[1
]
Ezzati, Mahnaz
[1
]
Madadi, Parinaz
[1
]
Marjani, Ahmad Poursattar
[1
]
Asl, Hooman Yaghoobnejad
[2
]
机构:
[1] Urmia Univ, Dept Organ Chem, Fac Chem, Orumiyeh, Iran
[2] Missouri Univ Sci & Technol, Dept Chem, Rolla, MO 65409 USA
来源:
SOUTH AFRICAN JOURNAL OF CHEMISTRY-SUID-AFRIKAANSE TYDSKRIF VIR CHEMIE
|
2017年
/
70卷
关键词:
Arylglyoxals;
L-cysteine;
1,3-dimethylbarbituric acid;
phosphotungstic acid;
one-pot;
multi-component reaction;
BARBITURIC-ACID DERIVATIVES;
ANTICANCER ACTIVITY;
WATER;
OXIDATION;
CONVENIENT;
RADICALS;
ANALOGS;
AMINES;
D O I:
10.17159/0379-4350/2017/v70a19
中图分类号:
O6 [化学];
学科分类号:
0703 ;
摘要:
This study reports the reduction of a, a-unsaturated ketones 4a-g, formed by condensation of arylglyoxals 2a-g with 1,3-dimethylbarbituric acid (3) by L-cysteine (5) in the presence of phosphotungstic acid as a catalyst. This reaction leads to the formation of 5-[2-aryl-2-oxoethyl]-1,3-dimethylpyrimidine-2,4,6-triones 6a-g, with no sign of any heterocyclic product formation. The structure of compound 6f was confirmed by X-ray crystallography.
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页码:132 / 136
页数:5
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