Synthesis of Some 5-[2-Aryl-2-oxoethyl]-1,3-dimethylpyrimidine-2,4,6-trione Derivatives by a One-pot, Three-component Reaction

被引：4
|
作者：
Khalafy, Jabbar [1 ]
Ezzati, Mahnaz [1 ]
Madadi, Parinaz [1 ]
Marjani, Ahmad Poursattar [1 ]
Asl, Hooman Yaghoobnejad [2 ]
机构：
[1] Urmia Univ, Dept Organ Chem, Fac Chem, Orumiyeh, Iran
[2] Missouri Univ Sci & Technol, Dept Chem, Rolla, MO 65409 USA
来源：
SOUTH AFRICAN JOURNAL OF CHEMISTRY-SUID-AFRIKAANSE TYDSKRIF VIR CHEMIE | 2017年 / 70卷
关键词：
Arylglyoxals; L-cysteine; 1,3-dimethylbarbituric acid; phosphotungstic acid; one-pot; multi-component reaction; BARBITURIC-ACID DERIVATIVES; ANTICANCER ACTIVITY; WATER; OXIDATION; CONVENIENT; RADICALS; ANALOGS; AMINES;
D O I：
10.17159/0379-4350/2017/v70a19
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This study reports the reduction of a, a-unsaturated ketones 4a-g, formed by condensation of arylglyoxals 2a-g with 1,3-dimethylbarbituric acid (3) by L-cysteine (5) in the presence of phosphotungstic acid as a catalyst. This reaction leads to the formation of 5-[2-aryl-2-oxoethyl]-1,3-dimethylpyrimidine-2,4,6-triones 6a-g, with no sign of any heterocyclic product formation. The structure of compound 6f was confirmed by X-ray crystallography.
引用
收藏
页码：132 / 136
页数：5
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