Protective effects of glucocorticoids on ischemia-reperfusion injury of outer hair cells

被引：29
|
作者：
Tabuchi, K [1 ]
Oikawa, K [1 ]
Murashita, H [1 ]
Hoshino, T [1 ]
Tsuji, S [1 ]
机构：
[1] Univ Tsukuba, Dept Otolaryngol, Grad Sch Comprehens Human Sci, Tsukuba, Ibaraki 3058575, Japan
来源：
LARYNGOSCOPE | 2006年 / 116卷 / 04期
关键词：
glucocorticoid; ischemia; outer hair cells;
D O I：
10.1097/01.mlg.0000200963.69342.d7
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Objective: This animal study aimed to investigate effects of glucocorticoids on the functional recovery of outer hair cells (OHCs) after transient ischemia. Methods: Distortion-product otoacoustic emission (DPOAE) was examined before, during, and after transient cochlear ischemia of 30 minutes using albino guinea pigs. Results: DPOAE decreased to noise level during ischemia. On recirculation, DPOAE initially recovered with time until 20 minutes after the onset of reperfusion, but thereafter; the DPOAE level gradually decreased toward the noise level in the control animals. Prednisolone and methylprednisolone significantly improved the DPOAE level 60 minutes after the onset of reperfusion. Conclusions: The present findings suggest that glucocorticoids possess protective effects against ischemia-reperfusion injury of OHCs.
引用
收藏
页码：627 / 629
页数：3
相关论文
共 50 条
  • [31] Protective effects of green tea on intestinal ischemia-reperfusion injury
    Abdeen, S. M.
    Mathew, T. C.
    Dashti, H. M.
    Asfar, S.
    NUTRITION, 2011, 27 (05) : 598 - 603
  • [32] Protective effects of polydatin on multiple organ ischemia-reperfusion injury
    Sun, Zhicheng
    Wang, Xiyang
    BIOORGANIC CHEMISTRY, 2020, 94
  • [33] Protective effects of evodiamine on myocardial ischemia-reperfusion injury in rats
    Rang, WQ
    Du, YH
    Hu, CP
    Ye, F
    Xu, KP
    Peng, J
    Deng, HW
    Li, YJ
    PLANTA MEDICA, 2004, 70 (12) : 1140 - 1143
  • [34] Protective effects of phenylalanine on ischemia-reperfusion injury in mouse heart
    Beijing Daxue Xuebao Ziran Kexue Ban/Acta Scientiarum uaturalium Universitatis Pekinensis, 1997, 33 (02): : 203 - 210
  • [35] PROTECTIVE EFFECTS OF REGULATORY T CELLS IN A MURINE MODEL OF RENAL ISCHEMIA-REPERFUSION INJURY
    Yamamoto, Ryohei
    Saito, Mitsuru
    Numakura, Kazuyuki
    Tsuruta, Hiroshi
    Maeno, Atushi
    Inoue, Takamitsu
    Narita, Shintaro
    Satoh, Shigeru
    Habuchi, Tomonori
    JOURNAL OF UROLOGY, 2017, 197 (04): : E1002 - E1002
  • [36] Is adalimumab protective in ischemia-reperfusion injury in lung?
    Kurt, Aysel
    Tumkaya, Levent
    Kalkan, Yildiray
    Turut, Hasan
    Cure, Medine Cumhur
    Cure, Erkan
    Sehitoglu, Ibrahim
    Bilgin, Hacer
    Usta, Mustafa
    IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2015, 18 (11) : 1093 - 1099
  • [37] The Protective of Baicalin on Myocardial Ischemia-Reperfusion Injury
    Liu, Xiaoli
    Zhang, Shanshan
    Xu, Chaoyue
    Sun, Yongchao
    Sui, Shujian
    Zhang, Zhaohua
    Luan, Yun
    CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2020, 21 (13) : 1386 - 1393
  • [38] Protective effects of MLIF analogs on cerebral ischemia-reperfusion injury in rats
    Yao, Jia
    Xu, Ying
    Ji, Fang
    Wang, Chao
    Zhang, Yun
    Ni, Jingman
    Wang, Rui
    PEPTIDES, 2011, 32 (05) : 1047 - 1054
  • [39] Protective Effects of Curcumin Against Ischemia-Reperfusion Injury in the Nervous System
    Bavarsad, Kowsar
    Barreto, George E.
    Hadjzadeh, Mousa-Al-Reza
    Sahebkar, Amirhossein
    MOLECULAR NEUROBIOLOGY, 2019, 56 (02) : 1391 - 1404
  • [40] Protective effects of xanthones against myocardial ischemia-reperfusion injury in rats
    Jiang, DJ
    Tan, GS
    Ye, F
    Du, YH
    Xu, KP
    Li, YJ
    ACTA PHARMACOLOGICA SINICA, 2003, 24 (02) : 175 - 180
12345