Protective effects of MLIF analogs on cerebral ischemia-reperfusion injury in rats

被引:15
|
作者
Yao, Jia [2 ,3 ,4 ]
Xu, Ying [5 ]
Ji, Fang [1 ]
Wang, Chao [1 ]
Zhang, Yun [1 ]
Ni, Jingman [1 ]
Wang, Rui [2 ,3 ,4 ]
机构
[1] Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China
[2] Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Sch Basic Med Sci, Lanzhou 730000, Peoples R China
[3] Lanzhou Univ, Inst Biochem & Mol Biol, Sch Life Sci, Lanzhou 730000, Peoples R China
[4] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
[5] Gansu Tumor Hosp, Gansu Prov Med Sci Inst, Lanzhou 730050, Gansu, Peoples R China
基金
中国国家自然科学基金;
关键词
Monocyte locomotion inhibitory factor; Neuroprotective; Anti-inflammatory; Inflammatory cytokine; N-terminal modified; INHIBITORY FACTOR MLIF; HUMAN MONOCYTE LOCOMOTION; ENTAMOEBA-HISTOLYTICA; ARTERY OCCLUSION; FOCAL ISCHEMIA; BRAIN-DAMAGE; TNF-ALPHA; EXPRESSION; STROKE; INTERLEUKIN-1-BETA;
D O I
10.1016/j.peptides.2011.03.005
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The monocyte locomotion inhibitory factor (MLIF) is an anti-inflammatory oligopeptide produced by Entamoeba histolytica. Among its different effects, it inhibits locomotion of human monocytes, hence its original name. The carboxyl-terminal end group Cys-Asn-Ser is the pharmacophore of anti-inflammatory peptide Met-Gln-Cys-Asn-Ser. In this study, the N-terminal of Cys-Asn-Ser was modified. With the aim to enhance the antioxidant ability and penetrability of Cys-Asn-Ser, we designed and synthesized two tetrapeptides Tyr-Cys-Asn-Ser and His-Cys-Asn-Ser. The neuroprotective effects of Tyr-Cys-Asn-Ser and His-Cys-Asn-Ser on focal ischemia reperfusion were investigated, and their pharmacological activities compared with Cys-Asn-Ser were studied. In order to study the mechanism of neuroprotective effect of these peptides, the level of oxidative stress markers malondialdehyde (MDA) and superoxide dismutase (SOD) and pro-inflammatory factors interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), and myeloperoxidase (MPO) were detected in brain tissue homogenate. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码:1047 / 1054
页数:8
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