In vivo evaluation of edge-loading in metal-on-metal hip resurfacing patients with pseudotumours

被引：27

作者：

Kwon, Y-M. ^{[1
]}

Mellon, S. J. ^{[1
]}

Monk, P. ^{[1
]}

Murray, D. W. ^{[1
]}

Gill, H. S. ^{[1
]}

机构：

[1] Univ Oxford, Nuffield Dept Rheumatol Orthopaed & Musculoskelet, Oxford OX3 7LD, England

来源：

BONE & JOINT RESEARCH | 2012年 / 1卷 / 04期

关键词：

Pseudotumours; Edge-loading; In vivo evaluation; Metal-on-metal; Hip resurfacing; Metal ions;

D O I：

10.1302/2046-3758.14.2000019

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Objectives Pseudotumours (abnormal peri-prosthetic soft-tissue reactions) following metal-on-metal hip resurfacing arthroplasty (MoMHRA) have been associated with elevated metal ion levels, suggesting that excessive wear may occur due to edge-loading of these MoM implants. This study aimed to quantify in vivo edge-loading in MoMHRA patients with and without pseudotumours during functional activities. Methods The duration and magnitude of edge-loading in vivo was quantified during functional activities by combining the dynamic hip joint segment contact force calculated from the three-dimensional (3D) motion analysis system with the 3D reconstruction of orientation of the acetabular component and each patient's specific hip joint centre, based on CT scans. Results Edge-loading in the hips with pseudotumours occurred with a four-fold increase in duration and magnitude of force compared with the hips without pseudotumours (p = 0.02). Conclusions The study provides the first in vivo evidence to support that edge-loading is an important mechanism that leads to localised excessive wear (edge-wear), with subsequent elevation of metal ion levels in MoMHRA patients with pseudotumours.

引用

页码：42 / 49

页数：8

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