Biomimetic Total Synthesis of Cruentaren A via Aromatization of Diketodioxinones

被引：47
|
作者：
Fouche, Marianne [1 ]
Rooney, Lisa [2 ]
Barrett, Anthony G. M. [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England
[2] Novartis, Horsham RH12 5AB, W Sussex, England
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 77卷 / 07期
基金：
欧洲研究理事会;
关键词：
TRANSANNULAR AROMATIZATION; BYSSOVORAX-CRUENTA; NATURAL-PRODUCTS; ALCOHOLS; ACIDS; MACROCYCLIZATION; ORGANOBORANES; ALDEHYDES; ANALOGS; OLEFINS;
D O I：
10.1021/jo300225z
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The total synthesis of cruentaren A, a biologically active resorcylate natural product, is reported. The aromatic unit was constructed via late-stage cyclization and aromatization from a diketodioxinone intermediate and macrocyclization using Furstner ring-closing alkyne metathesis.
引用
收藏
页码：3060 / 3070
页数：11
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