Biomimetic Total Synthesis of Cruentaren A via Aromatization of Diketodioxinones

被引：47

作者：

Fouche, Marianne ^{[1
]}

Rooney, Lisa ^{[2
]}

Barrett, Anthony G. M. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

[2] Novartis, Horsham RH12 5AB, W Sussex, England

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 77卷 / 07期

基金：

欧洲研究理事会;

关键词：

TRANSANNULAR AROMATIZATION; BYSSOVORAX-CRUENTA; NATURAL-PRODUCTS; ALCOHOLS; ACIDS; MACROCYCLIZATION; ORGANOBORANES; ALDEHYDES; ANALOGS; OLEFINS;

D O I：

10.1021/jo300225z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of cruentaren A, a biologically active resorcylate natural product, is reported. The aromatic unit was constructed via late-stage cyclization and aromatization from a diketodioxinone intermediate and macrocyclization using Furstner ring-closing alkyne metathesis.

引用

页码：3060 / 3070

页数：11

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