Discovery of novel natural alkaloid conessine as potent histamine H3 receptor antagonist

被引:0
|
作者
Zhao, C
Bennani, YL
Gopalakrishnan, S
Sun, M
Esbenshade, TA
Krueger, KM
Miller, TR
Witte, DG
Marsh, KC
Cowart, MD
Hancock, AA
机构
[1] Abbott Labs, GPRD, Dept Neurosci Res, Abbott Pk, IL 60064 USA
[2] Vertex Pharmaceut, Cambridge, MA 02139 USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
104-MEDI
引用
收藏
页码:U2568 / U2568
页数:1
相关论文
共 50 条
  • [31] Conjugated amides: Potent and selective histamine H3 receptor ligands
    Nirogi, Ramakrishna
    Shinde, Anil
    Mohammed, Abdul Rasheed
    Saraf, Sangram Keshri
    Bojja, Kumar
    Achanta, Pramodkumar
    Sastry, Kambhampati
    Subramanian, Ramkumar
    Bhyrapuneni, Gopinadh
    Muddana, Nageswara Rao
    Jayarajan, Pradeep
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 252
  • [32] Discovery of Novel Steroid-Based Histamine H3 Receptor Antagonists/Inverse Agonists
    Ledneczki, Istvan
    Tapolcsanyi, Pal
    Gabor, Eszter
    Eles, Janos
    Barabas, Julia
    Beni, Zoltan
    Varga, Balazs
    Balazs, Ottilia
    Roman, Viktor
    Fodor, Laszlo
    Szikra, Judit
    Vastag, Monika
    Levay, Gyorgy
    Schmidt, Eva
    Lendvai, Balazs
    Greiner, Istvan
    Kiss, Bela
    Nemethy, Zsolt
    Maho, Sandor
    JOURNAL OF MEDICINAL CHEMISTRY, 2024, 67 (05) : 3643 - 3667
  • [33] Discovery of New Highly Potent Histamine H3 Receptor Antagonists, Calcium Channel Blockers, and Acetylcholinesterase Inhibitors
    Malek, Rim
    Salat, Kinga
    Totoson, Perle
    Karcz, Tadeusz
    Refouvelet, Bernard
    Skrzypczak-Wiercioch, Anna
    Maj, Maciej
    Simakov, Alexey
    Martin, Helene
    Siwek, Agata
    Szalaj, Natalia
    Godyn, Justyna
    Panek, Dawid
    Wieckowska, Anna
    Jozwiak, Krzysztof
    Demougeot, Celine
    Kiec-Kononowicz, Katarzyna
    Chabchoub, Fakher
    Iriepa, Isabel
    Marco-Contelles, Jose
    Ismaili, Lhassane
    ACS CHEMICAL NEUROSCIENCE, 2024, 15 (18): : 3363 - 3383
  • [34] Discovery of substituted benzyl tetrazoles as histamine H3 receptor antagonists
    Davenport, Adam J.
    Stimson, Christopher C.
    Corsi, Massimo
    Vaidya, Darshan
    Glenn, Edward
    Jones, Timothy D.
    Bailey, Sarah
    Gemkow, Mark J.
    Fritz, Ulrike
    Hallett, David J.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (17) : 5165 - 5169
  • [35] The histamine H3 receptor: from discovery to clinical trials with pitolisant
    Schwartz, Jean-Charles
    BRITISH JOURNAL OF PHARMACOLOGY, 2011, 163 (04) : 713 - 721
  • [36] Anxiolytic and antidepressant-like activities of the novel and potent non-imidazole histamine H3 receptor antagonist ST-1283
    Bahi, Amine
    Schwed, Johannes Stephan
    Walter, Miriam
    Stark, Holger
    Sadek, Bassem
    DRUG DESIGN DEVELOPMENT AND THERAPY, 2014, 8 : 627 - 637
  • [37] Preclinical investigations into the antipsychotic potential of the novel histamine H3 receptor antagonist GSK207040
    Eric Southam
    Jackie Cilia
    Jane E. Gartlon
    Marie L. Woolley
    Laurent P. Lacroix
    Carol A. Jennings
    Jane E. Cluderay
    Charlie Reavill
    Claire Rourke
    David M. Wilson
    Lee A. Dawson
    Andrew D. Medhurst
    Declan N. C. Jones
    Psychopharmacology, 2009, 201 : 483 - 494
  • [38] Preclinical investigations into the antipsychotic potential of the novel histamine H3 receptor antagonist GSK207040
    Southam, Eric
    Cilia, Jackie
    Gartlon, Jane E.
    Woolley, Marie L.
    Lacroix, Laurent P.
    Jennings, Carol A.
    Cluderay, Jane E.
    Reavill, Charlie
    Rourke, Claire
    Wilson, David M.
    Dawson, Lee A.
    Medhurst, Andrew D.
    Jones, Declan N. C.
    PSYCHOPHARMACOLOGY, 2009, 201 (04) : 483 - 494
  • [39] Antiobesity effects of A-331440, a novel non-imidazole histamine H3 receptor antagonist
    Hancock, AA
    Bennani, YL
    Bush, EN
    Esbenshade, TA
    Faghih, R
    Fox, GB
    Jacobson, P
    Knourek-Segel, V
    Krueger, KM
    Nuss, ME
    Pan, JB
    Shapiro, R
    Witte, DG
    Yao, BB
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2004, 487 (1-3) : 183 - 197