Geroprotective Effect of Ala-Glu-Asp-Gly Peptide in Male Rats Exposed to Different Illumination Regimens

被引：3
|
作者：
Vinogradova, I. A. [2 ]
Bukalev, A. V. [2 ]
Zabezhinski, M. A. [1 ]
Semenchenko, A. V. [1 ]
Khavinson, V. Kh. [3 ]
Anisimov, V. N. [1 ]
机构：
[1] NN Petrov Inst Oncol, St Petersburg, Russia
[2] Petrozavodsk State Univ, St Petersburg, Russia
[3] Russian Acad Med Sci, St Petersburg Inst Bioregulat & Gerontol, North Western Div, Moscow 109801, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2008年 / 145卷 / 04期
基金：
俄罗斯基础研究基金会;
关键词：
photoregimen; epithalone peptide; lifespan; spontaneous tumors; male rats;
D O I：
10.1007/s10517-008-0121-7
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Exposure of male rats to permanent or natural illumination of North-Western Russia accelerated their death in comparison with animals exposed to standard (12 h) light. Permanent illumination promoted the development of spontaneous tumors in comparison with the standard photoregimen. Injection of epithalone (synthetic Ala-Glu-Asp-Gly peptide; subcutaneously 0.1 mu g/rat 5 times a week from the age of 4 months until natural death) virtually did not change the mean lifespan of male rats, but was associated with a significant (p < 0.05) normalization of population aging rate and hence, time of mortality rate doubling in groups exposed to natural or constant illumination. Epithalone injected to rats exposed to any photoregimen significantly inhibited the development of spontaneous tumors, primarily testicular leydigomas and leukemias.
引用
收藏
页码：472 / 477
页数：6
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    I. A. Vinogradova
    A. V. Bukalev
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    A. V. Semenchenko
    V. Kh. Khavinson
    V. N. Anisimov
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    [J]. Bulletin of Experimental Biology and Medicine, 2007, 144 : 825 - 830
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