Geroprotective Effect of Ala-Glu-Asp-Gly Peptide in Male Rats Exposed to Different Illumination Regimens

被引：3

作者：

Vinogradova, I. A. ^{[2
]}

Bukalev, A. V. ^{[2
]}

Zabezhinski, M. A. ^{[1
]}

Semenchenko, A. V. ^{[1
]}

Khavinson, V. Kh. ^{[3
]}

Anisimov, V. N. ^{[1
]}

机构：

[1] NN Petrov Inst Oncol, St Petersburg, Russia

[2] Petrozavodsk State Univ, St Petersburg, Russia

[3] Russian Acad Med Sci, St Petersburg Inst Bioregulat & Gerontol, North Western Div, Moscow 109801, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2008年 / 145卷 / 04期

基金：

俄罗斯基础研究基金会;

关键词：

photoregimen; epithalone peptide; lifespan; spontaneous tumors; male rats;

D O I：

10.1007/s10517-008-0121-7

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Exposure of male rats to permanent or natural illumination of North-Western Russia accelerated their death in comparison with animals exposed to standard (12 h) light. Permanent illumination promoted the development of spontaneous tumors in comparison with the standard photoregimen. Injection of epithalone (synthetic Ala-Glu-Asp-Gly peptide; subcutaneously 0.1 mu g/rat 5 times a week from the age of 4 months until natural death) virtually did not change the mean lifespan of male rats, but was associated with a significant (p < 0.05) normalization of population aging rate and hence, time of mortality rate doubling in groups exposed to natural or constant illumination. Epithalone injected to rats exposed to any photoregimen significantly inhibited the development of spontaneous tumors, primarily testicular leydigomas and leukemias.

引用

页码：472 / 477

页数：6

共 31 条

[21] LACK OF EFFECT OF THE PEPTIDE PYRO-GLU-HIS-GLY-OH ON FOOD-CONSUMPTION IN MICE AND RATS
BLAVET, N
DEFEUDIS, FV
CLOSTRE, F
[J]. GENERAL PHARMACOLOGY, 1982, 13 (02): : 173 - 176
[22] Melatonin prevents the development of the metabolic syndrome in male rats exposed to different light/dark regimens
Vinogradova, Irina
Anisimov, Vladimir
[J]. BIOGERONTOLOGY, 2013, 14 (04) : 401 - 409
[23] Melatonin prevents the development of the metabolic syndrome in male rats exposed to different light/dark regimens
Irina Vinogradova
Vladimir Anisimov
[J]. Biogerontology, 2013, 14 : 401 - 409
[24] THE PEPTIDE GLU-HIS-ISO-PRO-ALA, PREDICTED BY THE CODON SEQUENCE FOR ARG-GLY-ASP-VAL IN THE VITRONECTIN MESSENGER-RNA, DIMINISHES PLATELET-ADHESION TO FIBRINOGEN COATED POLYETHYLENE CONDUITS
JOHNSON, PC
TAYLOR, DB
GARTNER, TK
[J]. ARTERIOSCLEROSIS, 1990, 10 (05): : A939 - A939
[25] EFFECT OF SELF-ASSOCIATION ON THE CONFORMATION OF GASTRIN-RELATED PEPTIDES - CD STUDY ON PGLU-(GLU)4- ALA-TYR-GLY-TRP-NLE-ASP-PHE AMIDE
PEGGION, E
FOFFANI, MT
MORODER, L
WUNSCH, E
[J]. BIOPOLYMERS, 1985, 24 (11) : 2029 - 2033
[26] LONG-TERM SENSITIZATION TO THE ACTIVATION OF CEREBRAL DELTA-OPIOID RECEPTORS BY THE DELTORPHIN TYR-D-ALA-PHE-GLU-VAL-VAL-GLY-NH2 IN RATS EXPOSED TO MORPHINE
MELCHIORRI, P
MARITATI, M
NEGRI, L
ERSPAMER, V
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (09) : 3696 - 3700
[27] The effect of different alcohols on the Asp23-Lys28 and Asp23-Ala42 salt bridges of the most effective peptide in Alzheimer's disease: Molecular dynamics viewpoints
Jahanbin, Farnaz
Bozorgmehr, Mohammad Reza
Morsali, Ali
Beyramabadi, S. Ali
[J]. JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2019, 86 : 199 - 208
[28] THE EFFECT OF DIFFERENT DRUGS ON DRUG-SEEKING BEHAVIOR OF PRENATALLY METHAMPHETAMINE-EXPOSED ADULT MALE RATS
Slamberova, R.
Schutova, B.
Hruba, L.
Pometlova, M.
[J]. BEHAVIOURAL PHARMACOLOGY, 2011, 22 : E31 - E31
[29] Effect of Exogenous Melatonin Treatment on the Reproductive Characteristics and Progeny of Male Rats Exposed to Different Periods From Light and Darkness
Majrashi, K. A. A.
Barakat, I. A. H.
Al-Himaidi, A. R.
Adham, K. G.
[J]. PHYSIOLOGICAL RESEARCH, 2017, 66 (03) : 507 - 518
[30] EFFECT OF CHRONIC ETHANOL-CONSUMPTION ON INVIVO PROTEIN-SYNTHESIS IN LIVERS FROM FEMALE AND MALE-RATS FED 2 DIFFERENT DIET REGIMENS
SMITHKIELLAND, A
SVENDSEN, L
BESSESEN, A
MORLAND, J
[J]. ALCOHOL AND ALCOHOLISM, 1983, 18 (04): : 285 - 292

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