Geroprotective effect of Ala-Glu-Asp-Gly peptide in male rats exposed to different illumination regimens

被引：0
|
作者：
I. A. Vinogradova
A. V. Bukalev
M. A. Zabezhinski
A. V. Semenchenko
V. Kh. Khavinson
V. N. Anisimov
机构：
[1] Petrozavodsk State University,N. N. Petrov Institute of Oncology
[2] Rosmedtekhnologies,St. Petersburg Institute of Bioregulation and Gerontology
[3] North-Western Division of Russian Academy of Medical Sciences,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2008年 / 145卷
关键词：
photoregimen; epithalone peptide; lifespan; spontaneous tumors; male rats;
D O I：
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中图分类号：
学科分类号：
摘要：
Exposure of male rats to permanent or natural illumination of North-Western Russia accelerated their death in comparison with animals exposed to standard (12 h) light. Permanent illumination promoted the development of spontaneous tumors in comparison with the standard photoregimen. Injection of epithalone (synthetic Ala-Glu-Asp-Gly peptide; subcutaneously 0.1 µg/rat 5 times a week from the age of 4 months until natural death) virtually did not change the mean lifespan of male rats, but was associated with a significant (p<0.05) normalization of population aging rate and hence, time of mortality rate doubling in groups exposed to natural or constant illumination. Epithalone injected to rats exposed to any photoregimen significantly inhibited the development of spontaneous tumors, primarily testicular leydigomas and leukemias.
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页码：472 / 477
页数：5
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    Vinogradova, I. A.
    Bukalev, A. V.
    Zabezhinski, M. A.
    Semenchenko, A. V.
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    V. Kh. Khavinson
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    [J]. Bulletin of Experimental Biology and Medicine, 2007, 144 : 825 - 830
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