Palladium-Catalyzed Allylic C-H Oxidative Annulation for Assembly of Functionalized 2-Substituted Quinoline Derivatives

被引：55
|
作者：
Li, Chunsheng [1 ]
Li, Jianxiao [1 ]
An, Yanni [1 ]
Peng, Jianwen [1 ]
Wu, Wanqing [1 ]
Jiang, Huanfeng [1 ]
机构：
[1] South China Univ Technol, Sch Chem & Chem Engn, Key Lab Funct Mol Engn Guangdong Prov, Guangzhou 510640, Guangdong, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 24期
基金：
中国国家自然科学基金;
关键词：
MOLECULAR-OXYGEN; TERMINAL ALKENES; EFFICIENT SYNTHESIS; BOND FORMATION; ALPHA-OLEFINS; ALKYLATION; AMINATION; CYCLIZATION; ACTIVATION; ARYLATION;
D O I：
10.1021/acs.joc.6b01909
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and practical palladium-catalyzed aerobic oxidative approach to afford functionalized 2-substituted quinolines in moderate to good yields from readily available allylbenzenes with aniline is developed. The present annulation process has high functional-group tolerance and high atom economy, making it a valuable and practical method in synthetic and medicinal chemistry. Moreover, this transformation is supposed to proceed through oxidation of allylic CH functionalization to form CC and CN bonds in one pot.
引用
收藏
页码：12189 / 12196
页数：8
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