Synthesis of 1,2,3-Triazole Analogues of Lincomycin

被引：25

作者：

Collin, Marie-Pierre ^{[1
]}

Hobbie, Sven N. ^{[2
]}

Boettger, Erik C. ^{[2
]}

Vasella, Andrea ^{[1
]}

机构：

[1] ETH, Organ Chem Lab, Dept Chem & Angew Biowissensch, HCI Honggerberg, CH-8093 Zurich, Switzerland

[2] Univ Zurich, Inst Med Mikrobiol, CH-8006 Zurich, Switzerland

来源：

HELVETICA CHIMICA ACTA | 2008年 / 91卷 / 10期

关键词：

D O I：

10.1002/hlca.200890196

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In search for ne v antibiotics we replaced the amide moiety of lincomycin I by a 1,23-triazole ring. The 1.2,3-triazoles 10a-10k were obtained as single regioisomers by 'click reaction' of azide 5 with the alkyne 9k, derived from propyl hygric acid, and the alkyl, aryl, or cycloalkyl alkynes ribosomes 9a-9j. The new analogues proved inactive towards wild-type and A2058G mutant.

引用

页码：1838 / 1848

页数：11

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