Opioid receptors in the ventral tegmental area contribute to stress-induced analgesia in the formalin test for tonic pain

被引：32
|
作者：
Altier, N [1 ]
Stewart, J [1 ]
机构：
[1] CONCORDIA UNIV, DEPT PSYCHOL, CTR STUDIES BEHAV NEUROBIOL, MONTREAL, PQ H3G 1M8, CANADA
来源：
BRAIN RESEARCH | 1996年 / 718卷 / 1-2期
基金：
英国医学研究理事会; 加拿大自然科学与工程研究理事会;
关键词：
ventral tegmental areal; naltrexone methylbromide; formalin test; dopamine; footshock stress; opioid; analgesia;
D O I：
10.1016/0006-8993(96)00121-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Exposure to stress can induce analgesia in the formalin test for tonic pain. Here, we report that blockade of opioid receptors by bilateral infusions of naltrexone methylbromide (NMB) (0.1 mu g/0.5 mu l/side) in the ventral tegmental area (VTA) in the midbrain can reduce stress-induced analgesia in this test. These findings indicate that endogeneous opioids act in the VTA to mediate stress-induced analgesia in tonic pain.
引用
收藏
页码：203 / 206
页数：4
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