Opioid receptors in the ventral tegmental area contribute to stress-induced analgesia in the formalin test for tonic pain

被引：32

作者：

Altier, N ^{[1
]}

Stewart, J ^{[1
]}

机构：

[1] CONCORDIA UNIV, DEPT PSYCHOL, CTR STUDIES BEHAV NEUROBIOL, MONTREAL, PQ H3G 1M8, CANADA

来源：

BRAIN RESEARCH | 1996年 / 718卷 / 1-2期

基金：

英国医学研究理事会; 加拿大自然科学与工程研究理事会;

关键词：

ventral tegmental areal; naltrexone methylbromide; formalin test; dopamine; footshock stress; opioid; analgesia;

D O I：

10.1016/0006-8993(96)00121-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Exposure to stress can induce analgesia in the formalin test for tonic pain. Here, we report that blockade of opioid receptors by bilateral infusions of naltrexone methylbromide (NMB) (0.1 mu g/0.5 mu l/side) in the ventral tegmental area (VTA) in the midbrain can reduce stress-induced analgesia in this test. These findings indicate that endogeneous opioids act in the VTA to mediate stress-induced analgesia in tonic pain.

引用

页码：203 / 206

页数：4

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