Inflammatory properties of antibiotic-treated bacteria

被引:22
|
作者
Wolf, Andrea J. [1 ,2 ]
Liu, George Y. [2 ,3 ]
Underhill, David M. [1 ,2 ]
机构
[1] Cedars Sinai Med Ctr, F Widjaja Fdn Inflammatory Bowel & Immunobiol Res, Los Angeles, CA 90048 USA
[2] Cedars Sinai Med Ctr, Dept Biomed Sci, Div Immunol, Los Angeles, CA 90048 USA
[3] Cedars Sinai Med Ctr, Div Pediat Infect Dis, Los Angeles, CA 90048 USA
基金
美国国家卫生研究院;
关键词
peptidoglycan; Staphylococcus aureus; autolysis; beta-lactam; RESISTANT STAPHYLOCOCCUS-AUREUS; INDUCED ENDOTOXIN RELEASE; SUBINHIBITORY CONCENTRATIONS; PSEUDOMONAS-AERUGINOSA; BETA-LACTAM; AMINOGLYCOSIDE ANTIBIOTICS; LISTERIA-MONOCYTOGENES; GENE-EXPRESSION; VIRULENCE; PEPTIDOGLYCAN;
D O I
10.1189/jlb.4MR0316-153RR
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Antibiotics have proven to be enormously effective tools in combating infectious diseases. A common roadblock to the effective use of antibiotics is the development of antibiotic resistance. We have recently observed that the very mechanism by which methicillin-resistant Staphylococcus aureus (MRSA) becomes antibiotic resistant causes the organism to be more inflammatory to innate immune cells. In this review, we offer some thoughts on the ways in which antibiotics have been observed to influence immune responses to bacteria.
引用
收藏
页码:127 / 134
页数:8
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