EBV associated tumors have increased regulatory T cell recruitment and are therefore a potential indication for treatment with potent and selective small molecule CCR4 antagonists

被引：0

作者：

Talay, Oezcan ^{[1
]}

Jorapur, Aparna ^{[1
]}

Jacobson, Scott ^{[1
]}

Marubayashi, Sachie ^{[1
]}

Marshall, Lisa ^{[1
]}

Suthram, Silpa ^{[1
]}

Robles, Omar ^{[1
]}

Ketcham, John ^{[1
]}

Reilly, Maureen K. ^{[1
]}

Younai, Ashkaan ^{[1
]}

Biannic, Berenger ^{[1
]}

Hu, Dennis ^{[1
]}

Bui, Minna ^{[1
]}

Schwarz, Jacob ^{[1
]}

Kassner, Paul ^{[1
]}

Cutler, Gene ^{[1
]}

机构：

[1] FLX Bio, San Francisco, CA USA

来源：

CANCER RESEARCH | 2018年 / 78卷 / 13期

关键词：

D O I：

10.1158/1538-7445.AM2018-4752

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

4752

引用

页数：2

共 5 条

[1] Small-Molecule CCR4 Antagonists in Cutaneous T-cell Lymphoma
Enriquez, Jose S.
Wang, Xiaohong
Velatooru, Loka Reddy
Han, Wei
Bijani, Pedram
Ni, Xiao
CANCER RESEARCH COMMUNICATIONS, 2024, 4 (10): : 2756 - 2765
[2] Targeting regulatory T cells in vaccination: In silico identified small molecule CCR4 antagonists exert adjuvant activity
Bayr, Jagadeesh
Tchilian, Elma Z.
Davies, Matthew N.
Beverley, Peter C. L.
Flower, Darren R.
Tough, David F.
JOURNAL OF IMMUNOLOGY, 2009, 182
[3] CCR4 antagonists inhibit regulatory T cell (Treg) recruitment and increase effector T cell (Teff) numbers in the tumor microenvironment potentiating an anti-tumor response
Talay, Oezcan
Marshall, Lisa
Meleza, Cesar
Reilly, Maureen
Robles, Omar
Zibinsky, Mikhail
Okal, Abood
McKinnell, Jenny
Jacobson, Scott
Riegler, Erin
Marubayashi, Sashie
Karbarz, Emily
Chian, David
Wadsworth, Angela
Wustrow, David
Fridman, Jordan
Kassner, Paul
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2017, 5
[4] Potent and selective C-C chemokine receptor (CCR4) antagonists potentiate anti-tumor immune responses by inhibiting regulatory T cells (Treg)
Talay, Oezcan
Marshall, Lisa
Meleza, Cesar
Reilly, Maureen K.
Robles, Omar
Zibisky, Mikhail
Okal, Abood
Seitz, Lisa
McKinnell, Jenny
Jacobson, Scott
Riegler, Erin
Karbaz, Emily
Chian, David
Wadsworth, Angela
Kassner, Paul
Wustrow, David
Fridman, Jordan S.
CANCER RESEARCH, 2017, 77
[5] A CCR4 antagonist enhances DC activation and homing to the regional lymph node and shows potent vaccine adjuvant activity through the inhibition of regulatory T-cell recruitment
Yamamoto, Shinya
Matsuo, Kazuhiko
Nagakubo, Daisuke
Higashiyama, Shintaro
Nishiwaki, Keiji
Oiso, Naoki
Kawada, Akira
Yoshie, Osamu
Nakayama, Takashi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2018, 136 (03) : 165 - 171

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