CCR4 antagonists inhibit regulatory T cell (Treg) recruitment and increase effector T cell (Teff) numbers in the tumor microenvironment potentiating an anti-tumor response

被引:0
|
作者
Talay, Oezcan [1 ]
Marshall, Lisa [1 ]
Meleza, Cesar [1 ]
Reilly, Maureen [1 ]
Robles, Omar [1 ]
Zibinsky, Mikhail [1 ]
Okal, Abood [1 ]
McKinnell, Jenny [1 ]
Jacobson, Scott [1 ]
Riegler, Erin [1 ]
Marubayashi, Sashie [1 ]
Karbarz, Emily [1 ]
Chian, David [1 ]
Wadsworth, Angela [1 ]
Wustrow, David [1 ]
Fridman, Jordan [1 ]
Kassner, Paul [1 ]
机构
[1] FLX Bio Inc, San Francisco, CA USA
来源
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
P467
引用
收藏
页数:1
相关论文
共 50 条
  • [1] CCR4 Antagonists Inhibit Treg Trafficking into the Tumor Microenvironment
    Ketcham, John M.
    Marshall, Lisa A.
    Talay, Oezcan
    ACS MEDICINAL CHEMISTRY LETTERS, 2018, 9 (10): : 953 - 955
  • [2] A novel CCR4 antagonist induces potent anti-tumor response through inhibition of Treg migration into the tumor microenvironment
    Nair, Rashmi
    Abbineni, Chandrasekhar
    Talluri, Krishna Chaitanya
    Dhudashiya, Amit A.
    Aravind, A. B.
    Kumar, Naveen R.
    Ramya, R.
    Balasubramanyam, D.
    Obanna, Pathur
    Madhaiyan, Rabin
    Samiulla, D. S.
    Daginakatte, Girish
    Narayanan, Kishore
    Nellore, Kavitha
    Chelur, Shekar
    Samajdar, Susanta
    Ramachandra, Murali
    CANCER RESEARCH, 2024, 84 (06)
  • [3] Potent and selective C-C chemokine receptor (CCR4) antagonists potentiate anti-tumor immune responses by inhibiting regulatory T cells (Treg)
    Talay, Oezcan
    Marshall, Lisa
    Meleza, Cesar
    Reilly, Maureen K.
    Robles, Omar
    Zibisky, Mikhail
    Okal, Abood
    Seitz, Lisa
    McKinnell, Jenny
    Jacobson, Scott
    Riegler, Erin
    Karbaz, Emily
    Chian, David
    Wadsworth, Angela
    Kassner, Paul
    Wustrow, David
    Fridman, Jordan S.
    CANCER RESEARCH, 2017, 77
  • [4] TUMOR MICROENVIRONMENT INFILTRATING MYELOID DERIVED SUPPRESSOR CELLS INHIBIT ANTI-TUMOR T CELL RESPONSES
    Kamran, Neha
    Ayala, Mariela
    Li, Youping
    Assi, Hikmat
    Candolfi, Marianela
    Dzaman, Marta
    Lowenstein, Pedro
    Castro, Maria
    NEURO-ONCOLOGY, 2014, 16
  • [5] Selective regulatory T cell depletion by anti-CCR8 antibody enhances anti-tumor immunity
    Ohkura, Naganari
    Yasumizu, Yoshiaki
    Hagiwara, Masaki
    Kidani, Yujiro
    Fuji, Hiroaki
    Iwaisako, Keiko
    Nakamura, Yamami
    Sakaguchi, Shimon
    CANCER SCIENCE, 2025, 116 : 806 - 806
  • [6] INTERFERON-α AUGMENTS REGULATORY T CELL (TREG) DEPLETION TO BOOST ANTI-TUMOR IMMUNITY AND CLINICAL RESPONSE IN OVARIAN CANCER
    Thibodeaux, S.
    Wall, S.
    Ludwig, S.
    Kious, M.
    Lai, A.
    Jeansonne, D.
    Sun, X.
    Lomada, D.
    Daniel, B.
    Curiel, T.
    JOURNAL OF INVESTIGATIVE MEDICINE, 2010, 58 (02) : 483 - 483
  • [7] Dendritic Cells in Shaping Anti-Tumor T Cell Response
    Mazzoccoli, Luciano
    Liu, Bei
    CANCERS, 2024, 16 (12)
  • [8] Manipulation of T cell activation in the anti-tumor immune response
    Hurwitz, AA
    Leach, DR
    van Elsas, A
    Townsend, SE
    Allison, JP
    BIOLOGY OF TUMORS, 1998, : 213 - 222
  • [9] Impaired Anti-Tumor T cell Response in Hepatocellular Carcinoma
    Chaoul, Nada
    Mancarella, Serena
    Lupo, Luigi
    Giannelli, Gianluigi
    Dituri, Francesco
    CANCERS, 2020, 12 (03)
  • [10] The immunoreceptor TIGIT regulates anti-tumor and anti-viral T cell effector function
    Grogan, J.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, 46 : 327 - 327