CCR4 antagonists inhibit regulatory T cell (Treg) recruitment and increase effector T cell (Teff) numbers in the tumor microenvironment potentiating an anti-tumor response

被引：0

作者：

Talay, Oezcan ^{[1
]}

Marshall, Lisa ^{[1
]}

Meleza, Cesar ^{[1
]}

Reilly, Maureen ^{[1
]}

Robles, Omar ^{[1
]}

Zibinsky, Mikhail ^{[1
]}

Okal, Abood ^{[1
]}

McKinnell, Jenny ^{[1
]}

Jacobson, Scott ^{[1
]}

Riegler, Erin ^{[1
]}

Marubayashi, Sashie ^{[1
]}

Karbarz, Emily ^{[1
]}

Chian, David ^{[1
]}

Wadsworth, Angela ^{[1
]}

Wustrow, David ^{[1
]}

Fridman, Jordan ^{[1
]}

Kassner, Paul ^{[1
]}

机构：

[1] FLX Bio Inc, San Francisco, CA USA

来源：

JOURNAL FOR IMMUNOTHERAPY OF CANCER | 2017年 / 5卷

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

P467

引用

页数：1

共 50 条

[21] Intratumoral injection of α-gal glycolipids induces a protective anti-tumor T cell response which overcomes Treg activity
Abdel-Motal, Ussama M.
Wigglesworth, Kim
Galili, Uri
CANCER IMMUNOLOGY IMMUNOTHERAPY, 2009, 58 (10) : 1545 - 1556
[22] Intratumoral injection of α-gal glycolipids induces a protective anti-tumor T cell response which overcomes Treg activity
Ussama M. Abdel-Motal
Kim Wigglesworth
Uri Galili
Cancer Immunology, Immunotherapy, 2009, 58
[23] INVESTIGATING THE T CELL-INTRINSIC REGULATORY ROLE OF VISTA IN ANTI-TUMOR IMMUNITY
Gilmour, Cassandra
Wang, Yikun
Patnaik, Sachin
Stone, Sarah
Wang, Li
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 : A483 - A483
[24] Thymoquinone treatment enhances T cell-mediated anti-tumor response
Pandey, Rachana
Sirbu, Cristian
Hankins, Gerald
Fandy, Tamer
Du, Wei
JOURNAL OF IMMUNOLOGY, 2023, 210 (01):
[25] Improving anti-tumor response by increasing mitochondrial respiration of T-cell
Wu, Meng-Han
Giddlings, Emily
Danis, Catherine
McCalab, Megan
Kohler, Mark Eric
Rincon, Mercedes
CANCER RESEARCH, 2022, 82 (12)
[26] Antibodies to Costimulatory Receptor 4-1BB Enhance Anti-tumor Immunity via T Regulatory Cell Depletion and Promotion of CD8 T Cell Effector Function
Buchan, Sarah L.
Dou, Lang
Remer, Marcus
Booth, Steven G.
Dunn, Stuart N.
Lai, Chester
Semmrich, Monika
Teige, Ingrid
Martensson, Linda
Penfold, Christine A.
Chan, H. T. Claude
Willoughby, Jane E.
Mockridge, C. Ian
Dahal, Lekh N.
Cleary, Kirstie L. S.
James, Sonya
Rogel, Anne
Kannisto, Paivi
Jernetz, Mats
Williams, Emily L.
Healy, Eugene
Verbeek, J. Sjef
Johnson, Peter W. M.
Frendeus, Bjorn
Cragg, Mark S.
Glennie, Martin J.
Gray, Juliet C.
Al-Shamkhani, Aymen
Beers, Stephen A.
IMMUNITY, 2018, 49 (05) : 958 - +
[27] THE IN-VITRO MEASURE OF T CELL AVIDITY BETWEEN TUMOR-EFFECTOR PAIRS, NOT AFFINITY, PREDICTS OPTIMAL ANTI-TUMOR RESPONSE IN VIVO
Moser, Justin
Bar-Ephraim, Yotam
Eberlein, Jens
Bailey, Keith
Hoang, Song-My
Candelli, Andrea
Singleterry, Will
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 : A192 - A192
[28] EBV associated tumors have increased regulatory T cell recruitment and are therefore a potential indication for treatment with potent and selective small molecule CCR4 antagonists
Talay, Oezcan
Jorapur, Aparna
Jacobson, Scott
Marubayashi, Sachie
Marshall, Lisa
Suthram, Silpa
Robles, Omar
Ketcham, John
Reilly, Maureen K.
Younai, Ashkaan
Biannic, Berenger
Hu, Dennis
Bui, Minna
Schwarz, Jacob
Kassner, Paul
Cutler, Gene
CANCER RESEARCH, 2018, 78 (13)
[29] Elevated FoxP3+CD4+ CD25+ regulatory T cells in tumor-bearing mice suppress T-cell priming, effector-cell function and anti-tumor immunity
Liu, Zuqiang
Noh, Hae S.
Kim, Jin H.
Chen, Janet
Falo, Louis D., Jr.
You, Zhaoyang
JOURNAL OF IMMUNOTHERAPY, 2007, 30 (08) : 880 - 880
[30] Crucial role of dendritic cells in the generation of anti-tumor T-cell responses and immunogenic tumor microenvironment to suppress tumor development
Tominaga, Moe
Uto, Tomofumi
Fukaya, Tomohiro
Mitoma, Shuya
Riethmacher, Dieter
Umekita, Kunihiko
Yamashita, Yoshihiro
Sato, Katsuaki
FRONTIERS IN IMMUNOLOGY, 2024, 15

← 1 2 3 4 5 →