Genetic and Chromosomal Aberrations and Their Clinical Significance in Renal Neoplasms

被引：20
|
作者：
Yap, Ning Yi [1 ]
Rajandram, Retnagowri [1 ,2 ,3 ]
Ng, Keng Lim [1 ,2 ]
Pailoor, Jayalakshmi [4 ]
Fadzli, Ahmad [1 ]
Gobe, Glenda Carolyn [2 ]
机构：
[1] Univ Malaya, Fac Med, Dept Surg, Kuala Lumpur, Malaysia
[2] Univ Queensland, Translat Res Inst, Ctr Kidney Dis Res, Brisbane, Qld 4102, Australia
[3] Univ Malaya, Canc Res Inst, Kuala Lumpur, Malaysia
[4] Univ Malaya, Fac Med, Dept Pathol, Kuala Lumpur, Malaysia
来源：
BIOMED RESEARCH INTERNATIONAL | 2015年 / 2015卷
关键词：
VON-HIPPEL-LINDAU; TUMOR-SUPPRESSOR GENE; COLLECTING DUCT CARCINOMA; SPINDLE-CELL CARCINOMA; METASTATIC METANEPHRIC ADENOMA; EXPRESSION INDUCES APOPTOSIS; DISEASE-SPECIFIC SURVIVAL; HYPOXIA-INDUCIBLE FACTORS; FHIT PROTEIN EXPRESSION; DNA COPY NUMBER;
D O I：
10.1155/2015/476508
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The most common form of malignant renal neoplasms is renal cell carcinoma (RCC), which is classified into several different subtypes based on the histomorphological features. However, overlaps in these characteristics may present difficulties in the accurate diagnosis of these subtypes, which have different clinical outcomes. Genomic and molecular studies have revealed unique genetic aberrations in each subtype. Knowledge of these genetic changes in hereditary and sporadic renal neoplasms has given an insight into the various proteins and signalling pathways involved in tumour formation and progression. In this review, the genetic aberrations characteristic to each renal neoplasm subtype are evaluated along with the associated protein products and affected pathways. The potential applications of these genetic aberrations and proteins as diagnostic tools, prognostic markers, or therapeutic targets are also assessed.
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页数：22
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