Analysis and clinical significance of chromosomal testing results for eugenics and genetic testing

Objective: To investigate the clinical significance of chromosomal testing for adverse pregnancy outcomes by studying the relationship between chromosomal test results of the eugenics and genetic testing and adverse pregnancy outcomes. Methods: A total of 2,831 couples with eugenics and genetic testing from January 2014 to December 2015 in our hospital were retrospectively analyzed and 218 couples with adverse pregnancy outcomes were selected as research subjects in this study. Chromosomal testing results and general information such as age and childbearing history of all the research subjects were collected and all the research data were statistically analyzed. Results: It was found that 218 out of 2831 couples who did eugenic examination gave abnormal birth, with a rate of 7.7%. It was also found that the age of the women when at pregnancy was higher than their normal counterparts. Thetermination of pregnancy ranked highest of the abnormal birth in the study, accounting for 54.59%, followed by fetal malformation and stillbirth. For the chromosomal analysis of the 218 couples who give imperfect births, 45 of them were diagnosed as unusual, with a rate of 10.32%. There was no such a case that both of two in a couple were chromosomal abnormal. The chromosomal abnormality rate of female (12.84%) was higher than that of male (7.80%) (P = 0.001). The most common chromosomal abnormality was the balanced translocation (51.11%), which caused 60.87% of termination of pregnancy. The detectable rate of chromosomal abnormality in defective infants was the highest, followed by abortion and fetal malformation. Conclusion: Maternal chromosomal abnormality is more inclined to be detected in adverse pregnancy outcomes, and balanced translocation was the most common chromosomal abnormality in adverse pregnancy outcomes.