Synthesis of Nτ-arylhistidine derivatives via direct N-arylation

被引：12

作者：

Yue, WM ^{[1
]}

Lewis, SI ^{[1
]}

Koen, YM ^{[1
]}

Hanzlik, RP ^{[1
]}

机构：

[1] Univ Kansas, Dept Med Chem, Lawrence, KS 66045 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 07期

关键词：

N-arylation; aryl halides; histidine derivatives; Ullmann type coupling;

D O I：

10.1016/j.bmcl.2004.01.058

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

N-tau-Aryl-histidine derivatives were synthesized using a modified one-step Cu-catalyzed coupling of aryl halides and N-acetylhistidine methyl ester. The latter is much less reactive than imidazole toward aryl halides. p-Chloroiodobenzene coupled with iodine displacement only, whereas m- and p-bromoiodobenzene both gave mixtures of bromo- and iodophenyl products. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1637 / 1640

页数：4

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