Synthesis of N-aryl-2-substituted tetrahydrobenzimidazoles via direct N-arylation

被引：0
|
作者：
Li, Mei-Ying [1 ]
Liu, He [1 ]
Zhong, Bo-Hua [1 ]
机构：
[1] Beijing Inst Pharmacol & Toxicol, Dept Med Chem, Beijing, Peoples R China
来源：
SYNTHETIC COMMUNICATIONS | 2007年 / 37卷 / 4-6期
关键词：
N-arylation; hydrogenation; selective cyclooxygenase-2 inhibitors; tetrahydrobenzimidazole;
D O I：
10.1080/00397910601168249
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of novel N-aryl-2-substituted tetrahydrobenzimidazoles has been synthesized via direct N-arylation of 2-substituted tetrahydrobenzimidazoles, which was accomplished by a medium aryl electrophile, 4-methylsulfonylfluorobenze, in the presence of 37% KF/Al2O3 and 18-crown-6 in fair yields under mild reaction conditions. Meanwhile, the hydrogenation of 2-phenylbenzimidazole was studied.
引用
收藏
页码：1001 / 1009
页数：9
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