Ketamine-induced c-Fos expression in the mouse posterior cingulate and retrosplenial cortices is mediated not only via NMDA receptors but also via sigma receptors

被引：29

作者：

Nakao, S ^{[1
]}

Miyamoto, E ^{[1
]}

Masuzawa, M ^{[1
]}

Kambara, T ^{[1
]}

Shingu, K ^{[1
]}

机构：

[1] Kansai Med Univ, Dept Anesthesiol, Moriguchi, Osaka 5708507, Japan

来源：

BRAIN RESEARCH | 2002年 / 926卷 / 1-2期

关键词：

ketamine; NMDA receptor antagonist; sigma receptor; c-fos; posterior cingulate and retrosplenial cortices;

D O I：

10.1016/S0006-8993(01)03338-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Ketamine induces marked c-fos expression in the posterior cingulate and retrosplenial cortices (PC/RS). We investigated whether NMDA and/or sigma receptors were involved in the c-Fos expression. The number of Fos-LI positive boutons in NMDA receptor knockout mice was significantly lower than that in wild-type mice. Rimcazole but not haloperidol significantly suppressed the c-Fos expression. The results indicate that the ketamine-induced c-Fos expression is mediated not only via NMDA receptors but also via sigma receptors. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：191 / 196

页数：6

共 34 条

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