Ketamine-induced c-Fos expression in the mouse posterior cingulate and retrosplenial cortices is mediated not only via NMDA receptors but also via sigma receptors

被引：29
|
作者：
Nakao, S [1 ]
Miyamoto, E [1 ]
Masuzawa, M [1 ]
Kambara, T [1 ]
Shingu, K [1 ]
机构：
[1] Kansai Med Univ, Dept Anesthesiol, Moriguchi, Osaka 5708507, Japan
来源：
BRAIN RESEARCH | 2002年 / 926卷 / 1-2期
关键词：
ketamine; NMDA receptor antagonist; sigma receptor; c-fos; posterior cingulate and retrosplenial cortices;
D O I：
10.1016/S0006-8993(01)03338-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Ketamine induces marked c-fos expression in the posterior cingulate and retrosplenial cortices (PC/RS). We investigated whether NMDA and/or sigma receptors were involved in the c-Fos expression. The number of Fos-LI positive boutons in NMDA receptor knockout mice was significantly lower than that in wild-type mice. Rimcazole but not haloperidol significantly suppressed the c-Fos expression. The results indicate that the ketamine-induced c-Fos expression is mediated not only via NMDA receptors but also via sigma receptors. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：191 / 196
页数：6
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