Nicotine metabolism by the polymorphic cytochrome P450 2A6 (CYP2A6) enzyme: Implications for interindividual differences in smoking behaviour target article on nicotine-addiction

被引：0
|
作者：
Oscarson, M [1 ]
机构：
[1] Karolinska Inst, Div Mol Toxicol, Natl Inst Environm Med, SE-17177 Stockholm, Sweden
来源：
PSYCOLOQUY | 2001年 / 12卷 / 03期
关键词：
nicotine; cytochrome P450; CYP2A6; drug metabolism; genetic polymorphism; genotype; phenotype;
D O I：
暂无
中图分类号：
B84 [心理学];
学科分类号：
04 ; 0402 ;
摘要：
Cytochrome P450 2A6 (CYP2A6) is one of the most important enzymes in human nicotine metabolism. Genetic polymorphisms in the CYP2A6 gene causes important interindividual variability in CYP2A6 activity and this variation can explain some of the interindividual variability in nicotine metabolism previously reported. Here I summarise the current knowledge about the CYP2A6 polymorphism, and also discuss the potential importance of this polymorphism for differences in smoking behaviour.
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页码：1 / 6
页数：6
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