Genetic polymorphisms in human Cyp2a6 gene and interindividual differences in nicotine metabolism

被引：0
|
作者：
Nakajima, M [1 ]
Yoshida, R [1 ]
Nishimura, K [1 ]
Kwon, JT [1 ]
Yokoi, T [1 ]
机构：
[1] Kanazawa Univ, Fac Pharmaceut Sci, Div Drug Metab, Kanazawa, Ishikawa 920, Japan
来源：
CYTOCHROMES P450, BIOCHEMISTRY, BIOPHYSICS AND DRUG METABOLISM | 2003年
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We determined the phenotyping of in vivo nicotine metabolism and the genotyping of the CYP2A6 gene in 92 Japanese and 209 Koreans. Among them, 3 Japanese and 4 Korean subjects who were absolutely deficient in cotinine formation were genotyped as CYP2A6*4 (whole deletion)/CYP2A6*4. The other poor metabolizers whose nicotine metabolism was impaired were genotyped as CYP2A6*4/CYP2A6*7 (I471T) or CYP2A6*4/CYP2A6*10 (I471T, R485L). The cotinine/nicotine ratio as an index of nicotine metabolism could be put in the order of subjects genotyped as CYP2A6*1A/CYP2A6*1A > CYP2A6*1A/ CYP2A6*9 (T-48G) > CYP2A6*9/CYP2A6*9. Thus, nicotine metabolism was impaired by CYP2A6*4, CYP2A6*7, and CYP2A6*10 alleles and was decreased by CYP2A6*9 allele.
引用
收藏
页码：257 / 260
页数：4
相关论文
共 50 条
  • [1] Interindividual differences in nicotine metabolism and genetic polymorphisms of human CYP2A6
    Nakajima, M
    Kuroiwa, Y
    Yokoi, T
    DRUG METABOLISM REVIEWS, 2002, 34 (04) : 865 - +
  • [2] Interindividual differences in nicotine metabolism and genetic polymorphisms of human CYP2A6
    Yokoi, Tsuyoshi
    DRUG METABOLISM REVIEWS, 2006, 38 : 10 - 11
  • [3] Genetic polymorphisms in the cytochrome P450 2A6 (CYP2A6) gene:: Implications for interindividual differences in nicotine metabolism
    Oscarson, M
    DRUG METABOLISM AND DISPOSITION, 2001, 29 (02) : 91 - 95
  • [4] Genetic polymorphisms in human CYP2A6 gene causing impaired nicotine metabolism
    Yoshida, R
    Nakajima, M
    Watanabe, Y
    Kwon, JT
    Yokoi, T
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2002, 54 (05) : 511 - 517
  • [5] Relationship between interindividual differences in nicotine metabolism and CYP2A6 genetic polymorphism in humans
    Nakajima, M
    Kwon, JT
    Tanaka, N
    Zenta, T
    Yamamoto, Y
    Yamamoto, H
    Yamazaki, H
    Yamamoto, T
    Kuroiwa, Y
    Yokoi, T
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2001, 69 (01) : 72 - 78
  • [6] CYP2A6 gene polymorphisms impact to nicotine metabolism
    Muliaty, Dewi
    Yusuf, Irawan
    Setiabudy, Rianto
    Wanandi, Septelia I.
    MEDICAL JOURNAL OF INDONESIA, 2010, 19 (01) : 46 - 51
  • [7] The influence of CYP2A6 polymorphisms and cadmium on nicotine metabolism in Thai population
    Apinan, Roongnapa
    Tassaneeyakul, Wichittra
    Mahavorasirikul, Wiratchanee
    Satarug, Soisangwang
    Kajanawart, Sirimas
    Vannaprasaht, Suda
    Ruenweerayut, Ronnatrai
    Na-Bangchang, Kesara
    ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2009, 28 (03) : 420 - 424
  • [8] The role of CYP2A6*2 in nicotine metabolism
    Riexinger, A
    Collins, S
    Gaertner, I
    Farger, G
    Batra, A
    NICOTINE & TOBACCO RESEARCH, 2005, 7 (04) : 653 - 653
  • [9] CYP2A6 and CYP2B6 are involved in nornicotine formation from nicotine in humans: Interindividual differences in these contributions
    Yamanaka, H
    Nakajima, M
    Fukami, T
    Sakai, H
    Nakamura, A
    Katoh, M
    Takamiya, M
    Aoki, Y
    Yokoi, T
    DRUG METABOLISM AND DISPOSITION, 2005, 33 (12) : 1811 - 1818
  • [10] Gene-gene interactions between CYP2B6 and CYP2A6 in nicotine metabolism
    Ring, Huijun Z.
    Valdes, Ana M.
    Nishita, Denise M.
    Prasad, Suman
    Jacob, Peyton, III
    Tyndale, Rachel F.
    Swan, Gary E.
    Benowitz, Neal L.
    PHARMACOGENETICS AND GENOMICS, 2007, 17 (12): : 1007 - 1015
12345