Genetic polymorphisms in human Cyp2a6 gene and interindividual differences in nicotine metabolism

被引：0
|
作者：
Nakajima, M [1 ]
Yoshida, R [1 ]
Nishimura, K [1 ]
Kwon, JT [1 ]
Yokoi, T [1 ]
机构：
[1] Kanazawa Univ, Fac Pharmaceut Sci, Div Drug Metab, Kanazawa, Ishikawa 920, Japan
来源：
CYTOCHROMES P450, BIOCHEMISTRY, BIOPHYSICS AND DRUG METABOLISM | 2003年
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We determined the phenotyping of in vivo nicotine metabolism and the genotyping of the CYP2A6 gene in 92 Japanese and 209 Koreans. Among them, 3 Japanese and 4 Korean subjects who were absolutely deficient in cotinine formation were genotyped as CYP2A6*4 (whole deletion)/CYP2A6*4. The other poor metabolizers whose nicotine metabolism was impaired were genotyped as CYP2A6*4/CYP2A6*7 (I471T) or CYP2A6*4/CYP2A6*10 (I471T, R485L). The cotinine/nicotine ratio as an index of nicotine metabolism could be put in the order of subjects genotyped as CYP2A6*1A/CYP2A6*1A > CYP2A6*1A/ CYP2A6*9 (T-48G) > CYP2A6*9/CYP2A6*9. Thus, nicotine metabolism was impaired by CYP2A6*4, CYP2A6*7, and CYP2A6*10 alleles and was decreased by CYP2A6*9 allele.
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页码：257 / 260
页数：4
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