Nicotine metabolism by the polymorphic cytochrome P450 2A6 (CYP2A6) enzyme: Implications for interindividual differences in smoking behaviour target article on nicotine-addiction

被引：0

作者：

Oscarson, M ^{[1
]}

机构：

[1] Karolinska Inst, Div Mol Toxicol, Natl Inst Environm Med, SE-17177 Stockholm, Sweden

来源：

PSYCOLOQUY | 2001年 / 12卷 / 03期

关键词：

nicotine; cytochrome P450; CYP2A6; drug metabolism; genetic polymorphism; genotype; phenotype;

D O I：

暂无

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Cytochrome P450 2A6 (CYP2A6) is one of the most important enzymes in human nicotine metabolism. Genetic polymorphisms in the CYP2A6 gene causes important interindividual variability in CYP2A6 activity and this variation can explain some of the interindividual variability in nicotine metabolism previously reported. Here I summarise the current knowledge about the CYP2A6 polymorphism, and also discuss the potential importance of this polymorphism for differences in smoking behaviour.

引用

页码：1 / 6

页数：6

共 50 条

[21] Effects of Genetic Polymorphisms of Drug Transporter ABCB1 (MDR1) and Cytochrome P450 Enzymes CYP2A6, CYP2B6 on Nicotine Addiction and Smoking Cessation
Muderrisoglu, Ahmet
Babaoglu, Elif
Korkmaz, Elif Tugce
Ongun, Mert C.
Karabulut, Erdem
Iskit, Alper B.
Emri, Salih
Babaoglu, Melih O.
FRONTIERS IN GENETICS, 2020, 11
[22] Polymorphisms of nicotine metabolism genes CYP2A6 and CYP2B6 and their effect on smoking addiction in chinese han population
Wang, Hongjuan
Fu, Yaning
Chen, Huan
Liu, Tong
Han, Shulei
Hou, Hongwei
Hu, Qingyuan
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2020, 127 : 35 - 35
[23] Systematic Review of Naturally Derived Substances That Act as Inhibitors of the Nicotine Metabolizing Enzyme Cytochrome P450 2A6
Tzoupis, Haralampos
Papavasileiou, Konstantinos D.
Papatzelos, Stavros
Mavrogiorgis, Angelos
Zacharia, Lefteris C.
Melagraki, Georgia
Afantitis, Antreas
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (15)
[24] Cytochrome P450 2A6 (CYP2A6): a population genetics study using a new genotyping approach.
Zabetian, CP
Gelernter, J
Kranzler, HR
Cubells, JF
AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 65 (04) : A433 - A433
[25] Implications of CYP2A6 genetic variation for smoking behaviors and nicotine dependence
Malaiyandi, V
Sellers, EM
Tyndale, RF
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2005, 77 (03) : 145 - 158
[26] Functional Characterization of Allelic Variants of Polymorphic Human Cytochrome P450 2A6 (CYP2A6*5,*7,*8,*18,*19, and*35)
Han, Songhee
Choi, Seunghye
Chun, Young-Jin
Yun, Chul-Ho
Lee, Chang Hoon
Shin, Hee Jung
Na, Han Sung
Chung, Myeon Woo
Kim, Donghak
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2012, 35 (03) : 394 - 399
[27] Inhibitory Potency of 8-Methoxypsoralen on Cytochrome P450 2A6 (CYP2A6) Allelic Variants CYP2A6*15, CYP2A6*16, CYP2A6*21 and CYP2A6*22: Differential Susceptibility Due to Different Sequence Locations of the Mutations
Tiong, Kai Hung
Yunus, Nafees Ahemad Mohammed
Yiap, Beow Chin
Tan, Eng Lai
Ismail, Rusli
Ong, Chin Eng
PLOS ONE, 2014, 9 (01):
[28] CYP2A6 and CYP2B6 are involved in nornicotine formation from nicotine in humans: Interindividual differences in these contributions
Yamanaka, H
Nakajima, M
Fukami, T
Sakai, H
Nakamura, A
Katoh, M
Takamiya, M
Aoki, Y
Yokoi, T
DRUG METABOLISM AND DISPOSITION, 2005, 33 (12) : 1811 - 1818
[29] Pharmacotherapy effects on smoking cessation vary with nicotine metabolism gene (CYP2A6)
Chen, Li-Shiun
Bloom, A. Joseph
Baker, Timothy B.
Smith, Stevens S.
Piper, Megan E.
Martinez, Maribel
Saccone, Nancy
Hatsukami, Dorothy
Goate, Alison
Bierut, Laura
ADDICTION, 2014, 109 (01) : 128 - 137
[30] 2′-hydroxylation of nicotine by cytochrome P450 2A6 and human liver microsomes:: Formation of a lung carcinogen precursor
Hecht, SS
Hochalter, JB
Villalta, PW
Murphy, SE
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (23) : 12493 - 12497

← 1 2 3 4 5 →