The effects and mechanism of taxanes on chemotherapy-associated ovarian damage: A review of current evidence

被引：6
|
作者：
Wu, Chuqing [1 ,2 ,3 ]
Wu, Tong [1 ,2 ,3 ]
Chen, Dan [1 ,2 ,3 ]
Wei, Simin [1 ,2 ,3 ]
Tang, Weicheng [1 ,2 ,3 ]
Xue, Liru [1 ,2 ,3 ]
Xiong, Jiaqiang [4 ]
Huang, Yibao [1 ,2 ,3 ]
Guo, Yican [1 ,2 ,3 ]
Chen, Ying [1 ,2 ,3 ]
Wu, Meng [1 ,2 ,3 ]
Wang, Shixuan [1 ,2 ,3 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Obstet & Gynecol, Wuhan, Hubei, Peoples R China
[2] Natl Clin Res Ctr Obstetr & Gynecol Dis, Wuhan, Hubei, Peoples R China
[3] Minist Educ, Key Lab Canc Invas & Metastasis, Wuhan, Hubei, Peoples R China
[4] Wuhan Univ, Zhongnan Hosp, Dept Obstet & Gynecol, Wuhan, Hubei, Peoples R China
来源：
FRONTIERS IN ENDOCRINOLOGY | 2022年 / 13卷
基金：
中国国家自然科学基金;
关键词：
taxanes; chemotherapy; ovarian function; amenorrhea; fertility preservation; ANTI-MULLERIAN HORMONE; BREAST-CANCER PATIENTS; PRIMORDIAL FOLLICULAR RESERVE; INDUCED AMENORRHEA; FERTILITY PRESERVATION; PREMENOPAUSAL WOMEN; GRANULOSA-CELLS; MOUSE OOCYTES; FOLLOW-UP; AMERICAN-SOCIETY;
D O I：
10.3389/fendo.2022.1025018
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Chemotherapy is often a cause of premature ovarian insufficiency and infertility since the ovarian follicles are extremely sensitive to the effects of chemotherapeutic agents. Different chemotherapeutic agents with varying mechanisms of action may damage ovarian function differently. Taxanes are widely used in clinical cancer treatment, but the specific reproductive toxicological information is still controversial. This review described the impact and duration of taxanes on ovarian function in women and analyzed the possible reasons for different conclusions. Furthermore, the toxicity of taxanes on ovarian function and its possible mechanisms were discussed. The potential protective strategies and agents against ovarian damage induced by taxanes are also reviewed.
引用
收藏
页数：15
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