Synthesis, characterization and in vitro antitumour activity of the Di-n-butyltin(IV) complexes of some arylhydroxamates

被引：0

作者：

Wei, CY ^{[1
]}

Yang, P ^{[1
]}

Wang, LH ^{[1
]}

Wang, L ^{[1
]}

机构：

[1] Shanxi Univ, Inst Mol Sci, Shanxi 030006, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2002年 / 20卷 / 05期

关键词：

diorganotin; hydroxamic acid; antitumour activity;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Fourteen new di-n-butyltin(IV) complexes of hydroxamic acids of the formula Bu2SnL2(HL = hydroxamic acids) were synthesized by the reaction of Bu2SnO and hydroxamic acids in dry toluene and ethanol media. The compounds were characterized by elemental analyses, molecular weight, IR and (1) H NMR spectroscopy. The results indicate that n-Bu2SnL2 have distorted trans-octahedral structure. The antitumor activity in vitro against human A-549 tumor cells and P388 leukemia was presented, and their structure-activity relationship was discussed.

引用

页码：453 / 461

页数：9

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