Synthesis, characterization and in vitro antitumour activity of the Di-n-butyltin(IV) complexes of some arylhydroxamates

被引：0
|
作者：
Wei, CY [1 ]
Yang, P [1 ]
Wang, LH [1 ]
Wang, L [1 ]
机构：
[1] Shanxi Univ, Inst Mol Sci, Shanxi 030006, Peoples R China
来源：
CHINESE JOURNAL OF CHEMISTRY | 2002年 / 20卷 / 05期
关键词：
diorganotin; hydroxamic acid; antitumour activity;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Fourteen new di-n-butyltin(IV) complexes of hydroxamic acids of the formula Bu2SnL2(HL = hydroxamic acids) were synthesized by the reaction of Bu2SnO and hydroxamic acids in dry toluene and ethanol media. The compounds were characterized by elemental analyses, molecular weight, IR and (1) H NMR spectroscopy. The results indicate that n-Bu2SnL2 have distorted trans-octahedral structure. The antitumor activity in vitro against human A-549 tumor cells and P388 leukemia was presented, and their structure-activity relationship was discussed.
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页码：453 / 461
页数：9
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