Treatment of erosive vulvovaginal lichen planus with methotrexate

被引：35

作者：

Jang, Nelly ^{[1
]}

Fischer, Gayle ^{[1
,2
]}

机构：

[1] Royal N Shore Hosp, Dept Dermatol, St Leonards, NSW 2650, Australia

[2] Univ Sydney, Fac Med, No Clin Sch, Sydney, NSW 2006, Australia

来源：

AUSTRALASIAN JOURNAL OF DERMATOLOGY | 2008年 / 49卷 / 04期

关键词：

clobetasol dipropionate; corticosteroids; prednisone; tacrolimus;

D O I：

10.1111/j.1440-0960.2008.00472.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

We report the successful treatment of severe long-standing erosive vulvovaginal lichen planus in four adult female patients using 2.5-7.5 mg of oral methotrexate once weekly in conjunction with topical clobetasol dipropionate 0.05% ointment and tacrolimus 0.03-0.10% ointment. All cases experienced improvement in symptoms and healing of lesions within 4-8 weeks. Methotrexate was well tolerated and no adverse events have been observed in any of the patients at follow up 4-6 months later.

引用

页码：216 / 219

页数：4

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