Treatment of erosive vulvovaginal lichen planus with methotrexate

被引：35
|
作者：
Jang, Nelly [1 ]
Fischer, Gayle [1 ,2 ]
机构：
[1] Royal N Shore Hosp, Dept Dermatol, St Leonards, NSW 2650, Australia
[2] Univ Sydney, Fac Med, No Clin Sch, Sydney, NSW 2006, Australia
来源：
AUSTRALASIAN JOURNAL OF DERMATOLOGY | 2008年 / 49卷 / 04期
关键词：
clobetasol dipropionate; corticosteroids; prednisone; tacrolimus;
D O I：
10.1111/j.1440-0960.2008.00472.x
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
We report the successful treatment of severe long-standing erosive vulvovaginal lichen planus in four adult female patients using 2.5-7.5 mg of oral methotrexate once weekly in conjunction with topical clobetasol dipropionate 0.05% ointment and tacrolimus 0.03-0.10% ointment. All cases experienced improvement in symptoms and healing of lesions within 4-8 weeks. Methotrexate was well tolerated and no adverse events have been observed in any of the patients at follow up 4-6 months later.
引用
收藏
页码：216 / 219
页数：4
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