Comparison of histological structure and biocompatibility between human acellular dermal matrix (ADM) and porcine ADM

被引：70
|
作者：
Ge, Liangpeng [1 ]
Zheng, Shuquan [1 ]
Wei, Hong [1 ]
机构：
[1] Third Mil Med Univ, Dept Lab Anim Sci, Coll Basic Med, Chongqing, Peoples R China
来源：
BURNS | 2009年 / 35卷 / 01期
基金：
国家高技术研究发展计划(863计划);
关键词：
ADM; Porcine; Histological structure; Biocompatibility; RATS;
D O I：
10.1016/j.burns.2008.05.007
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
The present study was to compare the difference of histological structure and biocompatibility between human ADM and porcine ADM. The scaffold structure, collagen arrangement and collagen structure of human ADM and those of porcine ADM were very similar except for a slight difference in their black and white bands assessed by both light microscopy and electron microscopy. The positive immunohistochemical staining results of porcine ADM using human antibodies of collagen 1, collagen 111, collagen IV, fibronectin, laminin and vimentin and the result of SDS-PAGE implied a strong homology between the main proteins of human ADM and porcine ADM. In addition, statistical analysis indicated that there was no significant difference (P < 0.05) between the biocompatibility of the two ADMs. Based on these results, we conclude that porcine ADM bears a strong similarity to human ADM, and might be a substitute for human ADM in the future. (C) 2008 Elsevier Ltd and ISBI. All rights reserved.
引用
收藏
页码：46 / 50
页数：5
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