Palladium-catalyzed α-arylation of ketones on solid support:: scope and limitations

被引：9
|
作者：
Limbeck, M
Wamhoff, H
Rölle, T
Griebenow, N [1 ]
机构：
[1] Bayer HealthCare AG, Pharma Res, D-42096 Wuppertal, Germany
[2] Univ Bonn, Kekule Inst Organ Chem & Biochem, D-53121 Bonn, Germany
来源：
TETRAHEDRON LETTERS | 2006年 / 47卷 / 17期
关键词：
D O I：
10.1016/j.tetlet.2006.02.112
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The palladium-catalyzed alpha-arylation of ketones on solid support is described. Using modified Buchwald-Hartwig reaction conditions, the coupling of immobilized 4-bromobenzamide with various aromatic, heteroaromatic, and aliphatic ketones was investigated. Subsequent cleavage from the resin provided the desired alpha-aryl ketones almost in moderate to high yields and good to excellent purities. The scope and limitations of this protocol will be discussed. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2945 / 2948
页数：4
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