One-Pot Synthesis of 2,3,5-Trisubstituted Thiophenes through Three-Component Assembly of Arylacetaldehydes, Elemental Sulfur, and 1,3-Dicarbonyls

被引：49
|
作者：
Wang, Zilong [1 ]
Qu, Zhonghua [1 ]
Xiao, Fuhong [1 ]
Huang, Huawen [1 ]
Deng, Guo-Jun [1 ,2 ,3 ]
机构：
[1] Xiangtan Univ, Key Lab Environm Friendly Chem & Applicat, Key Lab Green Organ Synth & Applicat Hunan Prov, Minist Educ,Coll Chem, Xiangtan 411105, Peoples R China
[2] Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, Beijing 100190, Peoples R China
[3] Chinese Acad Sci, CAS Key Lab Mol Recognit & Funct, Inst Chem, Beijing 100190, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2018年 / 360卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Thiophenes; arylacetaldehydes; 1,3-dicarbonyls; elemental sulfur; one-pot; METAL-FREE CONDITIONS; C-H FUNCTIONALIZATION; REGIOSELECTIVE SYNTHESIS; MULTICOMPONENT REACTIONS; BOND FORMATION; TETRASUBSTITUTED THIOPHENES; BETA-KETOTHIOAMIDES; MOLECULAR-IODINE; KEY INTERMEDIATE; IN-SITU;
D O I：
10.1002/adsc.201701332
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The three-component reaction for the synthesis of 2-arylthiophenes has been developed. Easily available arylacetaldehydes, 1,3-dicarbonyls, and elemental sulfur were directly assembled through cascade condensation/ annulation under base conditions. The present protocol provides a facile entry to 2,3,5-trisubstituted thiophenes with moderate to excellent yields and good functional group tolerance.
引用
收藏
页码：796 / 800
页数：5
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