Synthesis and antirheumatic activity of novel tetrahydroquinoline-8-carboxylic acid derivatives

被引：7
|
作者：
Kohno, Y
Awano, K
Miyashita, M
Fujimori, S
Kuriyama, K
Sakoe, Y
Kudoh, S
Saito, K
Kojima, E
机构：
[1] Central Research Laboratories, Kyorin Pharmaceutical Co., Ltd.
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 12期
关键词：
D O I：
10.1016/S0960-894X(97)00261-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A study of the modification of N-alkylanthranilic acids to develop novel DMARDs is detailed. 1,2,3,4-Tetrahydroquinoline-8-carboxylic acid derivatives were found to exhibit a therapeutic effect on adjuvant arthritis and a suppressive effect on bone destruction. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码：1515 / 1518
页数：4
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