Synthesis and Antitubercular Activity of Novel Amino Acid Derivatives

被引：18

作者：

Da Costa, Cristiane F. ^{[1
,2
]}

Pinheiro, Alessandra C. ^{[1
]}

De Almeida, Mauro V. ^{[2
]}

Lourenco, Maria C. S. ^{[3
]}

De Souza, Marcus V. N. ^{[1
]}

机构：

[1] FioCruz Fundacao Oswaldo Cruz, Inst Tecnol Farmacos Farmanguinhos, BR-21041250 Rio De Janeiro, Brazil

[2] Univ Fed Juiz de Fora, Inst Ciencias Exatas, Dept Quim, BR-36036900 Juiz De Fora, MG, Brazil

[3] FioCruz Fundacao Oswaldo Cruz, Dept Bacteriol, Inst Pesquisas Clin Evandro Chagas, BR-21041250 Rio De Janeiro, Brazil

来源：

CHEMICAL BIOLOGY & DRUG DESIGN | 2012年 / 79卷 / 02期

关键词：

amino acids; cell wall; hydrazones; tuberculosis; MYCOBACTERIUM-TUBERCULOSIS; SUSCEPTIBILITY;

D O I：

10.1111/j.1747-0285.2011.01269.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this work, 17 new N-acylhydrazone derivatives of amino acids have been evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv. The compounds 8b, 8e, 8f, 9ad, and 10c exhibited an important minimum inhibitory concentration activity between 12.5 and 50 mu g/mL, which can be compared with that of the tuberculostatic drug d-cycloserine (20 mu g/mL).

引用

页码：216 / 222

页数：7

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