Synthesis and characterization of novel β-amino acid derivatives

被引：1

作者：

Liu, Yu-Ting ^{[1
,2
]}

Feng, Li ^{[1
,2
]}

Yin, Da-Wei ^{[1
,2
]}

机构：

[1] Shaanxi Univ Sci & Technol, Coll Chem & Chem Engn, Xian 710021, Peoples R China

[2] Shaanxi Univ Sci & Technol, Minist Educ, Key Lab Auxiliary Chem & Technol Chem Ind, Xian 710021, Peoples R China

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2013年 / 39卷 / 03期

关键词：

beta-Amino acid derivatives; Synthesis; Characterization; ANALOGS; ANTAGONISTS; INHIBITORS; PEPTIDES; ESTERS;

D O I：

10.1007/s11164-012-0601-2

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the work discussed in this paper, novel beta-amino acid derivatives were prepared by Michael addition between 3-substituted-2-propenic acid and hydrazine hydrate. The optimum reaction conditions were determined by analyzing the effects of the ratio of the starting materials, temperature, and reaction time. The conclusions were: reaction temperature 80 A degrees C, reaction time 8 h, n (3-substituted-2-propenic acid)/n (hydrazine hydrate) = 1:15. Products were characterized by measurement of melting point, elemental analysis, and IR and H-1 NMR spectroscopy.

引用

页码：875 / 880

页数：6

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