Synthesis, Characterization, and Biological Activity of Amino Acid Derivatives of the Heteropolytungstophosphoric Acid

被引：0
|
作者：
Vesna Kuntić
Maja Stanojević
Ivanka Holclajtner-Antunović
Snežana Uskoković-Marković
Ubavka Mioč
Marija Todorović
Tanja Jovanović
Vladana Vukojević
机构：
[1] University of Belgrade,Department of Physical Chemistry, Faculty of Pharmacy
[2] University of Belgrade,Institute of Microbiology and Immunology, Faculty of Medicine
[3] University of Belgrade,Faculty of Physical Chemistry
[4] University of Belgrade,Department of Analytical Chemistry, Faculty of Pharmacy
[5] University of Belgrade,Faculty of Chemistry
[6] Karolinska Institutet,undefined
[7] Center for Molecular Medicine,undefined
来源：
Monatshefte für Chemie / Chemical Monthly | 2006年 / 137卷
关键词：
Keywords. Heteropoly compounds; Amino acids; IR spectroscopy; Cellular toxicity; Antiviral activity.;
D O I：
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学科分类号：
摘要：
Compounds of phosphotungstic acid (WPA) containing the amino acids alanine (WPA–Ala) or glycine (WPA–Gly) as counter cations were synthesized and characterized by elemental analysis, thermal analysis, and IR spectroscopy. Cellular toxicity was assessed by the trypan blue exclusion method, and the antiviral activity of WPA and the modified WPA compounds was tested against herpes simplex viruses (HSV) type 1 and type 2. Biological assays indicate that the newly synthesized compounds exhibit no evident cytotoxic effects on Vero cells and negligible antiviral activity against HSV-1 and HSV-2.
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页码：803 / 810
页数：7
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