Synthesis of novel tetrapeptides as potential ACE inhibitors

被引：0
|
作者：
Tandon, R
Singh, MP
Haq, W
Dikshit, M
Patnaik, GK
Dhar, MM
机构：
[1] CENT DRUG RES INST,DIV BIOPOLYMERS,LUCKNOW 226001,UTTAR PRADESH,INDIA
[2] CENT DRUG RES INST,DIV PHARMACOL,LUCKNOW 226001,UTTAR PRADESH,INDIA
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 1997年 / 36卷 / 05期
关键词：
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Pepsin hydrolysis of wheat gluten yields a tetrapeptide, Leu-Gln-Pro-Arg (1) which exhibits potent ACE inhibitory activity. Analogues (2-7) of this peptide have been synthesized and examined for ACE inhibitory activity in vitro and in vivo. None of the compounds synthesized showed improved in vivo activity. However, compound 6 has been found to be as active as captopril in in vitro assay.
引用
收藏
页码：386 / 390
页数：5
相关论文
共 50 条
  • [1] Design and synthesis of α,β-unsaturated carbonyl compounds as potential ACE inhibitors
    Choo, HYP
    Peak, KH
    Park, J
    Kim, DH
    Chung, HS
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2000, 35 (06) : 643 - 648
  • [2] Synthesis and NMR elucidation of novel tetrapeptides
    Makatini, Maya
    Chetty, Thashini
    Onajole, Oluseye K.
    Govender, Thavendran
    Govender, Patrick
    Maguire, Glenn E. M.
    Kruger, Hendrik G.
    [J]. JOURNAL OF PEPTIDE SCIENCE, 2012, 18 (02) : 114 - 121
  • [3] ACE inhibitors increase type III collagen synthesis: A potential explanation for reduction in acute vascular events by ACE inhibitors
    Claridge, MW
    Hobbs, SD
    Quick, CR
    Day, NE
    Bradbury, AW
    Wilmink, ABM
    [J]. EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, 2004, 28 (01) : 67 - 70
  • [4] Epoxyalkanoyls as novel ACE inhibitors
    Hea-Young P. Choo
    Hea-Ran Yoon
    Hwha-Soon Park
    Dong-Hyun Kim
    Jongsei Park
    Dong H. Kim
    [J]. Archives of Pharmacal Research, 1998, 21 : 168 - 173
  • [5] SYNTHESIS OF CARBONYL-BISAMINOACID-DERIVATIVES AS POTENTIAL ACE-INHIBITORS
    HENKLEIN, P
    BOTTCHER, M
    HEDER, G
    SIEMS, WE
    NIEDRICH, H
    [J]. PHARMAZIE, 1986, 41 (01): : 56 - 57
  • [6] Epoxyalkanoyls as novel ACE inhibitors
    Choo, HYP
    Yoon, HR
    Park, HS
    Kim, DH
    Park, J
    Kim, J
    [J]. ARCHIVES OF PHARMACAL RESEARCH, 1998, 21 (02) : 168 - 173
  • [7] Histone deacetylase inhibitors: synthesis of cyclic tetrapeptides and their triazole analogs
    Singh, Erinprit K.
    Nazarova, Lidia A.
    Lapera, Stephanie A.
    Alexander, Leslie D.
    McAlpine, Shelli R.
    [J]. TETRAHEDRON LETTERS, 2010, 51 (33) : 4357 - 4360
  • [8] ACE inhibitors: A novel treatment for neurofibroma
    Namazi, Hamid
    [J]. ANNALS OF SURGICAL ONCOLOGY, 2008, 15 (05) : 1538 - 1539
  • [9] ACE Inhibitors: A Novel Treatment for Neurofibroma
    Hamid Namazi
    [J]. Annals of Surgical Oncology, 2008, 15 : 1538 - 1539
  • [10] Cyclic tetrapeptides containing a zinc ligand as novel histone deacetylase inhibitors
    Jose, B
    Kato, T
    Sumida, Y
    Yoshida, M
    Nishino, N
    [J]. BIOPOLYMERS, 2003, 71 (03) : 396 - 396
12345