Melatonin as a geroprotector:: Experiments with Drosophila melanogaster

被引：0
|
作者：
Izmailov, DM [1 ]
Obukhova, LK [1 ]
机构：
[1] Russian Acad Sci, NM Emanuel Inst Biochem Phys, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1999年 / 127卷 / 02期
关键词：
melatonin; lifespan; geroprotector; Drosophila melanogaster;
D O I：
10.1007/BF02433110
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The lifespan of D. melanogaster treated with melatonin in a concentration of 0.08% at the stage of development is studied. The geroprotective effect of melatonin is the most obvious (up to 12-18%) in comparison with controls with a short lifespan; if the controls' lifespan was relatively long, the hormone exerts negligible or toxic effect shortening the lifespan by up to 10%. Antioxidant mechanism of geroprotective effect of melatonin is discussed in light of the concept of fluctuations in the lifespan in successive D. melanogaster generations.
引用
收藏
页码：186 / 187
页数：2
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