Melatonin as a geroprotector:: Experiments with Drosophila melanogaster

被引：0

作者：

Izmailov, DM ^{[1
]}

Obukhova, LK ^{[1
]}

机构：

[1] Russian Acad Sci, NM Emanuel Inst Biochem Phys, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1999年 / 127卷 / 02期

关键词：

melatonin; lifespan; geroprotector; Drosophila melanogaster;

D O I：

10.1007/BF02433110

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The lifespan of D. melanogaster treated with melatonin in a concentration of 0.08% at the stage of development is studied. The geroprotective effect of melatonin is the most obvious (up to 12-18%) in comparison with controls with a short lifespan; if the controls' lifespan was relatively long, the hormone exerts negligible or toxic effect shortening the lifespan by up to 10%. Antioxidant mechanism of geroprotective effect of melatonin is discussed in light of the concept of fluctuations in the lifespan in successive D. melanogaster generations.

引用

页码：186 / 187

页数：2

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