Increased oxidative stress in children with attention deficit hyperactivity disorder

被引：45
|
作者：
Sezen, Hatice [1 ]
Kandemir, Hasan [2 ]
Savik, Emin [1 ]
Kandemir, Sultan Basmaci [3 ]
Kilicaslan, Fethiye [2 ]
Bilinc, Hasan [1 ]
Aksoy, Nurten [1 ]
机构：
[1] Harran Univ, Dept Clin Biochem, Fac Med, Sanliurfa, Turkey
[2] Harran Univ, Dept Child & Adolescent Psychiat, Fac Med, Sanliurfa, Turkey
[3] Balikligol State Hosp, Dept Psychiat, Sanliurfa, Turkey
来源：
REDOX REPORT | 2016年 / 21卷 / 06期
关键词：
Attention deficit hyperactivity disorder; Oxidative stress; Paraxonase-1; Arylesterase; ARYLESTERASE ACTIVITIES; SERUM PARAOXONASE; ADOLESCENT PATIENTS; AUTOMATED-METHOD; LIPID PROFILE; IMBALANCE; PREVALENCE; ADHD;
D O I：
10.1080/13510002.2015.1116729
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Objectives: The purpose of this study was to investigate oxidative stress in children with attention deficit hyperactivity disorder (ADHD). Methods: Total oxidant status (TOS), total antioxidant status (TAS), paraxonase-1 (PON-1) and arylesterase (ARE) activity were measured in 76 children (44 boys, 32 girls) diagnosed with ADHD according to the DSM-IV and 78 healthy children (46 boys, 32 girls). Results: Age and sex were similar between the groups (P > 0.05). TOS and the oxidative stress index (OSI) were higher in the patient group than the control group (P < 0.001). PON-1 (P = 0.002), ARE (P = 0.010) activity and TAS (P < 0.001) were lower in the patient group than the control group. Discussion: We found decreased PON-1, ARE activity and TAS, and increased TOS and OSI in children with ADHD. Our study showed that there is significantly increased oxidative stress in children with ADHD.
引用
收藏
页码：248 / 253
页数：6
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